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Tchem
TRAP1
Heat shock protein 75 kDa, mitochondrial

Protein Summary
Description
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246957
  • ENSP00000246957
  • ENSG00000126602
  • ENST00000538171
  • ENSP00000442070

Symbol
  • HSP75
  • HSP75
  • HSP 75
  • HSP90L
  • TRAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.96
kinase perturbation
0.93
histone modification site profile
0.9
hub protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.94   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 614   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.94   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 614   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (92)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (186)
1 – 10 of 186
ARSF
Tdark
Family: Enzyme
Novelty: 0.06295744
p_int: 0.999999971
p_ni: 2.9e-8
Data Source: BioPlex
FNBP4
Tdark
Novelty: 0.2068824
p_int: 0.97990539
p_ni: 0.015436623
p_wrong: 0.004657986
Data Source: BioPlex
DYNC1H1
Tbio
Novelty: 0.01357869
p_int: 0.915422609
p_ni: 0.084577391
Data Source: BioPlex
CDC5L
Tbio
Family: TF
Novelty: 0.00617757
Score: 0.98
Data Source: STRINGDB
SUGT1
Tbio
Novelty: 0.17606795
Score: 0.972
Data Source: STRINGDB
SDHB
Tbio
Family: Enzyme
Novelty: 0.0020679
Score: 0.943
Data Source: STRINGDB
PINK1
Tbio
Family: Kinase
Novelty: 0.00128084
Score: 0.94
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.04447104
Score: 0.933
Data Source: STRINGDB
SDHA
Tbio
Family: Enzyme
Novelty: 0.00476895
Score: 0.916
Data Source: STRINGDB
SDHC
Tbio
Family: Enzyme
Novelty: 0.00173432
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.94

PubMed score by year
PubTator Score  103.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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