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Tbio
KLRB1
Killer cell lectin-like receptor subfamily B member 1

Protein Summary
Description
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229402
  • ENSP00000229402
  • ENSG00000111796

Symbol
  • CLEC5B
  • NKRP1A
  • NKR
  • CD161
  • CLEC5B
  • NKR-P1
  • NKRP1A
  • NKR-P1A
  • hNKR-P1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.68
tissue sample
0.56
biological term
0.54
transcription factor perturbation
0.54
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.2   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 827   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.2   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 827   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
CLEC2D
Tbio
Novelty:  0.02501194
Score:  0.985
Data Source:  Reactome,STRINGDB
CLEC2A
Tbio
Novelty:  0.14656329
Score:  0.904
Data Source:  STRINGDB
GZMA
Tbio
Family:  Enzyme
Novelty:  0.00322362
Score:  0.869
Data Source:  STRINGDB
CD2
Tclin
Novelty:  0.00037283
Score:  0.862
Data Source:  STRINGDB
GZMB
Tchem
Family:  Enzyme
Novelty:  0.00052869
Score:  0.786
Data Source:  STRINGDB
GZMK
Tbio
Family:  Enzyme
Novelty:  0.01355915
Score:  0.783
Data Source:  STRINGDB
RORC
Tchem
Family:  NR
Novelty:  0.00509106
Score:  0.782
Data Source:  STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
Score:  0.752
Data Source:  STRINGDB
CCRL2
Tchem
Family:  GPCR
Novelty:  0.00294533
Score:  0.737
Data Source:  STRINGDB
PRF1
Tchem
Novelty:  0.0002835
Score:  0.72
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
2
0
1.1
88
1
1
0
1.6
14.2
1
1
1
9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
88
0
1.6
14.2
1
9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor B1
VGNC:8431
736832
Mouse
MGI:107540
17057
Mouse
MGI:2442965
232408
Rat
RGD:1583336
683758
Dog
killer cell lectin like receptor B1
VGNC:42485
100684789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor B1
Mouse
Mouse
Rat
Dog
killer cell lectin like receptor B1
Publication Statistics
PubMed Score 350.20
PubMed score by year
PubTator Score 186.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title