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Tbio
PTPRJ
Receptor-type tyrosine-protein phosphatase eta

Protein Summary
Description
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418331
  • ENSP00000400010
  • ENSG00000149177
  • ENST00000440289
  • ENSP00000409733

Symbol
  • DEP1
  • DEP1
  • SCC1
  • CD148
  • HPTPeta
  • R-PTP-ETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological process
0.98
microRNA
0.94
protein domain
0.85
transcription factor binding site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.04   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 465   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.04   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
3
5
96.9
venous thromboembolism
1
2
2
87.9
heel bone mineral density
2
1
2
74
testosterone measurement
1
1
1
60.4
body height
1
1
1
56.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
96.9
venous thromboembolism
2
87.9
heel bone mineral density
2
74
testosterone measurement
1
60.4
body height
1
56.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type J
VGNC:7675
451181
Macaque
protein tyrosine phosphatase, receptor type J
710347
Mouse
MGI:104574
19271
Rat
RGD:3454
29645
Dog
protein tyrosine phosphatase, receptor type J
VGNC:45190
483617
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type J
Macaque
protein tyrosine phosphatase, receptor type J
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type J
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12913-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (90)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Negative regulation of MET activity
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Innate Immune System
Negative regulation of MET activity
Neutrophil degranulation
Gene Ontology Terms (41)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (174)
1 – 10 of 174
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999999965
p_ni: 1.3e-8
p_wrong: 2.2e-8
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999999223
p_ni: 2.31e-7
p_wrong: 5.47e-7
Score: 0.299
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.999996753
p_ni: 0.000003188
p_wrong: 6e-8
Score: 0.552
Data Source: BioPlex,STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.977
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.97
Data Source: STRINGDB
CDH5
Tbio
Novelty: 0.00072649
Score: 0.967
Data Source: STRINGDB
MET
Tclin
Family: Kinase
Novelty: 0.00037995
Score: 0.959
Data Source: Reactome,STRINGDB
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00074896
Score: 0.953
Data Source: STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.95
Data Source: Reactome,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  151.04

PubMed score by year
PubTator Score  158.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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