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Tbio
LRMP
Lymphoid-restricted membrane protein

Protein Classes
Protein Summary
Description
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354454
  • ENSP00000346442
  • ENSG00000118308
  • ENST00000547044
  • ENSP00000450246
  • ENST00000548766
  • ENSP00000446496

Symbol
  • JAW1
  • JAW1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
PubMedID
0.78
cellular component
0.75
interacting protein
0.65
trait
0.61


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lymphoid restricted membrane protein
707643
Mouse
MGI:108424
16970
Dog
lymphoid restricted membrane protein
486631
Horse
lymphoid restricted membrane protein
100068768
Cow
lymphoid restricted membrane protein
100140494
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lymphoid restricted membrane protein
Mouse
Dog
lymphoid restricted membrane protein
Horse
lymphoid restricted membrane protein
Cow
lymphoid restricted membrane protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q12912-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (14)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (91)
1 – 10 of 91
RAB44
Tdark
Family:  Enzyme
Novelty:  0.16987153
Score:  0.912
Data Source:  STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.912
Data Source:  STRINGDB
NFAM1
Tbio
Novelty:  0.24235123
Score:  0.906
Data Source:  STRINGDB
CD68
Tbio
Novelty:  0.00017859
Score:  0.905
Data Source:  STRINGDB
RAB37
Tbio
Family:  Enzyme
Novelty:  0.07133253
Score:  0.905
Data Source:  STRINGDB
GLIPR1
Tbio
Novelty:  0.03474569
Score:  0.904
Data Source:  STRINGDB
ACPP
Tchem
Family:  Enzyme
Novelty:  0.00364265
Score:  0.904
Data Source:  STRINGDB
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
Score:  0.904
Data Source:  STRINGDB
FPR1
Tchem
Family:  GPCR
Novelty:  0.00256884
Score:  0.903
Data Source:  STRINGDB
ATP8A1
Tbio
Family:  Transporter
Novelty:  0.02003643
Score:  0.903
Data Source:  STRINGDB
Publication Statistics
PubMed Score  27.76

PubMed score by year
PubTator Score  12.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer