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Tclin
SLC10A2
Ileal sodium/bile acid cotransporter

Protein Summary
Description
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245312
  • ENSP00000245312
  • ENSG00000125255

Symbol
  • ASBT
  • ISBT
  • NTCP2
  • ASBT
  • IBAT
  • ISBT
  • PBAM
  • NTCP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
gene perturbation
0.85
microRNA
0.65
disease
0.6
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.25   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.25   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 200
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (200)
CHEMBL367757
Rendered image for CHEMBL367757
264W94
Rendered image for 264W94
SC-435
Rendered image for SC-435
CHEMBL363392,CHEMBL17879
Rendered image for CHEMBL363392,CHEMBL17879
CHEMBL370103
Rendered image for CHEMBL370103
CHEMBL364676
Rendered image for CHEMBL364676
CHEMBL555246
Rendered image for CHEMBL555246
CHEMBL194685
Rendered image for CHEMBL194685
CHEMBL372080
Rendered image for CHEMBL372080
CHEMBL195012
Rendered image for CHEMBL195012
Protein-Protein Interactions (78)
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.821450158
p_ni:  0.178549842
Score:  0.209
Data Source:  BioPlex,STRINGDB
FABP6
Tbio
Novelty:  0.00671588
Score:  0.982
Data Source:  STRINGDB
SLC51A
Tbio
Family:  Transporter
Novelty:  0.02128282
Score:  0.809
Data Source:  STRINGDB
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.805
Data Source:  STRINGDB
SLC51B
Tbio
Family:  Transporter
Novelty:  0.03325003
Score:  0.773
Data Source:  STRINGDB
CYP7A1
Tchem
Family:  Enzyme
Novelty:  0.00148194
Score:  0.768
Data Source:  STRINGDB
ABCB11
Tchem
Family:  Transporter
Novelty:  0.00097529
Score:  0.757
Data Source:  STRINGDB
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
Score:  0.752
Data Source:  STRINGDB
CYP8B1
Tchem
Family:  Enzyme
Novelty:  0.01243408
Score:  0.686
Data Source:  STRINGDB
NR0B2
Tchem
Family:  NR
Novelty:  0.0009861
Score:  0.684
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Bile acid and bile salt metabolism (R-HSA-194068)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Recycling of bile acids and salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Recycling of bile acids and salts
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 10 member 2
VGNC:7833
467318
Macaque
solute carrier family 10 member 2
702376
Mouse
MGI:1201406
20494
Rat
RGD:3682
29500
Dog
solute carrier family 10 member 2
VGNC:46212
403448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 10 member 2
Macaque
solute carrier family 10 member 2
Mouse
Rat
Dog
solute carrier family 10 member 2
Publication Statistics
PubMed Score 311.25
PubMed score by year
PubTator Score 263.90
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title