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Tbio
LMAN2
Vesicular integral-membrane protein VIP36

Protein Summary
Description
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303127
  • ENSP00000303366
  • ENSG00000169223

Symbol
  • C5orf8
  • GP36B
  • VIP36
  • C5orf8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
interacting protein
0.89
cellular component
0.81
transcription factor binding site profile
0.78
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.31   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.31   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (108)
1 – 10 of 108
CENPH
Tbio
Novelty:  0.02845079
p_int:  0.983559128
p_ni:  0.016440872
Score:  0.234
Data Source:  BioPlex,STRINGDB
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.946697222
p_ni:  0.037106633
p_wrong:  0.016196145
Score:  0.234
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.918382773
p_ni:  0.081617227
Score:  0.207
Data Source:  BioPlex,STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
p_int:  0.91179821
p_ni:  0.08820179
Score:  0.19
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.897133989
p_ni:  0.102866011
Score:  0.177
Data Source:  BioPlex,STRINGDB
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.800580587
p_ni:  0.199419413
Data Source:  BioPlex
TMED10
Tbio
Novelty:  0.02742083
Score:  0.989
Data Source:  STRINGDB
TMED2
Tbio
Novelty:  0.03731104
Score:  0.987
Data Source:  STRINGDB
MCFD2
Tbio
Novelty:  0.0402944
Score:  0.963
Data Source:  STRINGDB
CTSZ
Tchem
Family:  Enzyme
Novelty:  0.0100016
Score:  0.939
Data Source:  STRINGDB
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Membrane Trafficking
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (59)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
8
11
15.2
99.3
creatinine measurement
5
6
7
97
partial thromboplastin time
2
2
2
96.1
hematocrit
5
5
5
96.1
hemoglobin measurement
4
4
4
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
11
15.2
99.3
creatinine measurement
7
97
partial thromboplastin time
2
96.1
hematocrit
5
96.1
hemoglobin measurement
4
94.3
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lectin, mannose binding 2
VGNC:6942
462302
Macaque
lectin, mannose binding 2
723005
Mouse
MGI:1914140
66890
Rat
RGD:1308965
290994
Dog
lectin, mannose binding 2
VGNC:42708
403938
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lectin, mannose binding 2
Macaque
lectin, mannose binding 2
Mouse
Rat
Dog
lectin, mannose binding 2
Publication Statistics
PubMed Score 36.31
PubMed score by year
PubTator Score 19.84
PubTator score by year