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Tbio
ILF2
Interleukin enhancer-binding factor 2

Protein Summary
Description
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361891
  • ENSP00000355011
  • ENSG00000143621

Symbol
  • NF45
  • NF45
  • PRO3063
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
hub protein
0.94
kinase perturbation
0.93
molecular function
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.22   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 383   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.22   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (359)
STRBP
Tbio
Novelty:  0.00919158
p_int:  0.999999592
p_ni:  4.08e-7
Score:  0.893
Data Source:  BioPlex,STRINGDB
ZFR
Tbio
Novelty:  0.01859772
p_int:  0.999949937
p_ni:  0.000050063
Score:  0.937
Data Source:  BioPlex,STRINGDB
ILF3
Tbio
Novelty:  0.00430826
p_int:  0.999863232
p_ni:  0.000136768
Score:  0.992
Data Source:  BioPlex,STRINGDB
RBMXL1
Tdark
Novelty:  0.81422952
p_int:  0.999469395
p_ni:  0.000530605
Score:  0.2
Data Source:  BioPlex,STRINGDB
PUM2
Tbio
Novelty:  0.01849765
p_int:  0.999303954
p_ni:  0.000694887
p_wrong:  0.000001159
Score:  0.686
Data Source:  BioPlex,STRINGDB
HNRNPR
Tbio
Novelty:  0.06568708
p_int:  0.998886118
p_ni:  0.001113882
Score:  0.98
Data Source:  BioPlex,STRINGDB
PRKRA
Tbio
Family:  Kinase
Novelty:  0.02115618
p_int:  0.996156471
p_ni:  0.003843529
Score:  0.575
Data Source:  BioPlex,STRINGDB
PRMT6
Tchem
Family:  Epigenetic
Novelty:  0.01734208
p_int:  0.989199208
p_ni:  0.010800764
p_wrong:  2.8e-8
Score:  0.282
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.986228732
p_ni:  0.013771268
Score:  0.269
Data Source:  BioPlex,STRINGDB
UPF1
Tbio
Novelty:  0.00311006
p_int:  0.983540391
p_ni:  0.016459609
Score:  0.418
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
24.4
monocyte count
1
1
1
9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
24.4
monocyte count
1
9
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin enhancer binding factor 2
VGNC:1272
107968444
Macaque
interleukin enhancer binding factor 2
715452
Mouse
MGI:1915031
67781
Rat
RGD:1305734
310612
Dog
interleukin enhancer binding factor 2
VGNC:41999
480139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin enhancer binding factor 2
Macaque
interleukin enhancer binding factor 2
Mouse
Rat
Dog
interleukin enhancer binding factor 2
Publication Statistics
PubMed Score 73.22
PubMed score by year
PubTator Score 41.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title