You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Protein Classes
Protein Summary
Description
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358008
  • ENSP00000350699
  • ENSG00000164022
  • ENST00000394701
  • ENSP00000378191
  • ENST00000442366
  • ENSP00000405248

Symbol
  • EMAP2
  • SCYE1
  • p43
  • HLD3
  • EMAP2
  • SCYE1
  • EMAPII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.88
virus perturbation
0.85
disease perturbation
0.83
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.51   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 540   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.51   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
77.8
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
HGNC
Protein-Protein Interactions (199)
1 – 10 of 199
OPTN
Tbio
Novelty: 0.00080427
p_int: 0.999997342
p_ni: 0.000002658
Score: 0.19
Data Source: BioPlex,STRINGDB
TARSL2
Tbio
Family: Enzyme
Novelty: 0.02406282
p_int: 0.999994292
p_ni: 0.000005708
Score: 0.931
Data Source: BioPlex,STRINGDB
RARS
Tchem
Family: Enzyme
Novelty: 0.00099479
p_int: 0.999993409
p_ni: 0.000006591
Score: 0.999
Data Source: BioPlex,STRINGDB
SDCBP
Tbio
Novelty: 0.00242211
p_int: 0.999764334
p_ni: 0.000235666
Score: 0.828
Data Source: BioPlex,STRINGDB
KARS
Tchem
Family: Enzyme
Novelty: 0.00386511
p_int: 0.9996742
p_ni: 0.0003258
Score: 0.998
Data Source: BioPlex,STRINGDB
AIMP2
Tbio
Family: Enzyme
Novelty: 0.03283387
p_int: 0.999495173
p_ni: 0.000504827
Score: 0.999
Data Source: BioPlex,STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
p_int: 0.999301177
p_ni: 0.000698823
Score: 0.998
Data Source: BioPlex,STRINGDB
EEF1E1
Tbio
Novelty: 0.06216577
p_int: 0.998215101
p_ni: 0.001784899
Score: 0.999
Data Source: BioPlex,STRINGDB
LARS
Tchem
Family: Enzyme
Novelty: 0.00361711
p_int: 0.99715385
p_ni: 0.00284615
Score: 0.998
Data Source: BioPlex,STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
p_int: 0.996684787
p_ni: 0.003315213
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  167.51

PubMed score by year
PubTator Score  164.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: