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Tbio
TMEM115
Transmembrane protein 115

Protein Summary
Description
May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266025
  • ENSP00000266025
  • ENSG00000126062

Symbol
  • PL6
  • PL6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
tissue sample
0.64
transcription factor binding site profile
0.63
tissue
0.6
transcription factor
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.999934471
p_ni:  0.000059038
p_wrong:  0.000006491
Score:  0.167
Data Source:  BioPlex,STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.976913444
p_ni:  0.000042184
p_wrong:  0.023044372
Score:  0.169
Data Source:  BioPlex,STRINGDB
COG4
Tbio
Novelty:  0.03809668
Score:  0.953
Data Source:  STRINGDB
COG5
Tbio
Novelty:  0.04017657
Score:  0.931
Data Source:  STRINGDB
COG1
Tbio
Novelty:  0.0124285
Score:  0.927
Data Source:  STRINGDB
GOSR1
Tbio
Novelty:  0.03139481
Score:  0.924
Data Source:  STRINGDB
COG7
Tbio
Novelty:  0.07137701
Score:  0.922
Data Source:  STRINGDB
COG3
Tbio
Novelty:  0.02746711
Score:  0.921
Data Source:  STRINGDB
COG8
Tbio
Novelty:  0.02448169
Score:  0.919
Data Source:  STRINGDB
COG6
Tbio
Novelty:  0.02874093
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
11
99.2
reticulocyte count
2
4
8
98.7
mean reticulocyte volume
1
1
1
85.1
chronotype measurement
1
1
0
1
66.8
macrophage inflammatory protein 1b measurement
1
2
2
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
11
99.2
reticulocyte count
8
98.7
mean reticulocyte volume
1
85.1
chronotype measurement
0
1
66.8
macrophage inflammatory protein 1b measurement
2
66.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 115
VGNC:2609
460395
Mouse
MGI:1930765
56395
Dog
transmembrane protein 115
VGNC:47452
484758
Cow
transmembrane protein 115
VGNC:35952
532459
Pig
transmembrane protein 115
100517191
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 115
Mouse
Dog
transmembrane protein 115
Cow
transmembrane protein 115
Pig
transmembrane protein 115
Publication Statistics
PubMed Score 44.94
PubMed score by year
PubTator Score 43.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title