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Tbio
HYAL2
Hyaluronidase-2

Protein Summary
Description
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes tw ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357750
  • ENSP00000350387
  • ENSG00000068001
  • ENST00000395139
  • ENSP00000378571
  • ENST00000442581
  • ENSP00000406657
  • ENST00000447092
  • ENSP00000401853

Symbol
  • LUCA2
  • LUCA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.94
cellular component
0.87
transcription factor binding site profile
0.82
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.38   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.38   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.999008084
p_ni:  0.000991912
p_wrong:  4e-9
Data Source:  BioPlex
DPEP2
Tbio
Family:  Enzyme
Novelty:  0.14691384
p_int:  0.996608775
p_ni:  0.003296425
p_wrong:  0.000094801
Score:  0.544
Data Source:  BioPlex,STRINGDB
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.993953787
p_ni:  0.006046174
p_wrong:  4e-8
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.990867066
p_ni:  0.009132934
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.989736637
p_ni:  0.006268815
p_wrong:  0.003994548
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.975864404
p_ni:  0.023444153
p_wrong:  0.000691443
Data Source:  BioPlex
FUT3
Tbio
Family:  Enzyme
Novelty:  0.0059835
p_int:  0.958980065
p_ni:  0.008750375
p_wrong:  0.03226956
Score:  0.179
Data Source:  BioPlex,STRINGDB
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.939223255
p_ni:  0.043240438
p_wrong:  0.017536307
Data Source:  BioPlex
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.9323135
p_ni:  0.067675101
p_wrong:  0.000011399
Score:  0.155
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.923658539
p_ni:  0.076330991
p_wrong:  0.00001047
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan metabolism
Reactome
Hyaluronan uptake and degradation
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Hyaluronan metabolism
Hyaluronan uptake and degradation
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (60)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
11
91.6
reticulocyte count
2
4
8
91
chronotype measurement
1
2
0
1
85.7
schizophrenia
4
2
0
1.1
83.3
mean reticulocyte volume
1
1
1
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
11
91.6
reticulocyte count
8
91
chronotype measurement
0
1
85.7
schizophrenia
0
1.1
83.3
mean reticulocyte volume
1
75.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
hyaluronoglucosaminidase 2
702484
Mouse
MGI:1196334
15587
Rat
RGD:620321
64468
Dog
hyaluronoglucosaminidase 2
VGNC:41843
484760
Cow
hyaluronoglucosaminidase 2
VGNC:30011
281838
Species
Name
OMA
EggNOG
Inparanoid
Macaque
hyaluronoglucosaminidase 2
Mouse
Rat
Dog
hyaluronoglucosaminidase 2
Cow
hyaluronoglucosaminidase 2
Publication Statistics
PubMed Score 154.38
PubMed score by year
PubTator Score 74.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title