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Tbio
OVGP1
Oviduct-specific glycoprotein

Protein Summary
Description
Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369732
  • ENSP00000358747
  • ENSG00000085465

Symbol
  • MUC9
  • OGP
  • EGP
  • OGP
  • MUC9
  • CHIT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
protein domain
0.73
cellular component
0.68
disease perturbation
0.68
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.13   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.13   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
AKAP10
Tbio
Family:  Enzyme
Novelty:  0.03517248
p_int:  0.999999765
p_ni:  4e-8
p_wrong:  1.94e-7
Data Source:  BioPlex
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
p_int:  0.999947941
p_ni:  0.000052056
p_wrong:  2e-9
Data Source:  BioPlex
ZNF460
Tdark
Family:  TF
Novelty:  0.71547663
p_int:  0.844782078
p_ni:  0.004006955
p_wrong:  0.151210967
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.832079216
p_ni:  0.167920784
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.799410188
p_ni:  0.200589812
Data Source:  BioPlex
ZP3
Tbio
Novelty:  0.00140352
Score:  0.929
Data Source:  STRINGDB
ZP4
Tbio
Novelty:  0.00655772
Score:  0.92
Data Source:  STRINGDB
ADAM2
Tbio
Family:  Enzyme
Novelty:  0.00586482
Score:  0.911
Data Source:  STRINGDB
ZP2
Tbio
Novelty:  0.00310166
Score:  0.905
Data Source:  STRINGDB
ZP1
Tbio
Novelty:  0.16160314
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Interaction With Cumulus Cells And The Zona Pellucida
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Fertilization
Interaction With Cumulus Cells And The Zona Pellucida
Reproduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
energy intake measurement
1
1
0
145
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
energy intake measurement
0
145
15.8
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oviductal glycoprotein 1
VGNC:1436
100616518
Macaque
oviductal glycoprotein 1
703848
Mouse
MGI:106661
12659
Dog
oviductal glycoprotein 1 [Source:HGNC Symbol;Acc:HGNC:8524]
Cow
oviductal glycoprotein 1
281962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oviductal glycoprotein 1
Macaque
oviductal glycoprotein 1
Mouse
Dog
oviductal glycoprotein 1 [Source:HGNC Symbol;Acc:HGNC:8524]
Cow
oviductal glycoprotein 1
Publication Statistics
PubMed Score 162.13
PubMed score by year
PubTator Score 75.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title