You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
OVGP1
Oviduct-specific glycoprotein

Protein Summary
Description
Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369732
  • ENSP00000358747
  • ENSG00000085465

Symbol
  • MUC9
  • OGP
  • EGP
  • OGP
  • MUC9
  • CHIT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
protein domain
0.73
cellular component
0.68
disease perturbation
0.68
cell type or tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.92   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.92   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Interaction With Cumulus Cells And The Zona Pellucida
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Fertilization
Interaction With Cumulus Cells And The Zona Pellucida
Reproduction
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (35)
1 – 10 of 35
AKAP10
Tbio
Family: Enzyme
Novelty: 0.04172773
p_int: 0.999999765
p_ni: 4e-8
p_wrong: 1.94e-7
Data Source: BioPlex
PEX6
Tbio
Family: Enzyme
Novelty: 0.01134558
p_int: 0.999947941
p_ni: 0.000052056
p_wrong: 2e-9
Data Source: BioPlex
ZNF460
Tdark
Family: TF
Novelty: 3
p_int: 0.844782078
p_ni: 0.004006955
p_wrong: 0.151210967
Data Source: BioPlex
TUBA4A
Tchem
Novelty: 0.02626744
p_int: 0.832079216
p_ni: 0.167920784
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00051387
p_int: 0.799410188
p_ni: 0.200589812
Data Source: BioPlex
ZP3
Tbio
Novelty: 0.0015273
Score: 0.929
Data Source: STRINGDB
ZP4
Tbio
Novelty: 0.01081951
Score: 0.92
Data Source: STRINGDB
ADAM2
Tbio
Family: Enzyme
Novelty: 0.00672579
Score: 0.911
Data Source: STRINGDB
ZP2
Tbio
Novelty: 0.00383063
Score: 0.905
Data Source: STRINGDB
ZP1
Tbio
Novelty: 0.47619048
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  169.92

PubMed score by year
PubTator Score  75.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer