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Tbio
TP53BP1
TP53-binding protein 1

Protein Summary
Description
Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:1719060 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263801
  • ENSP00000263801
  • ENSG00000067369
  • ENST00000382044
  • ENSP00000371475
  • ENST00000450115
  • ENSP00000393497

Symbol
  • p202
  • 53BP1
  • TDRD30
  • p53BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase
0.9
transcription factor perturbation
0.88
virus perturbation
0.88
drug perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 821.73   (req: < 5)
Gene RIFs: 185   (req: <= 3)
Antibodies: 797   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 821.73   (req: >= 5)
Gene RIFs: 185   (req: > 3)
Antibodies: 797   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
95.1
triglyceride measurement
4
1
7
90.6
high density lipoprotein cholesterol measurement
4
1
7
90.5
hemoglobin measurement
2
2
2
88.6
hematocrit
2
2
2
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
95.1
triglyceride measurement
7
90.6
high density lipoprotein cholesterol measurement
7
90.5
hemoglobin measurement
2
88.6
hematocrit
2
87
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor protein p53 binding protein 1
VGNC:1588
467668
Macaque
tumor protein p53 binding protein 1
710237
Mouse
MGI:1351320
27223
Rat
RGD:1308039
296099
Dog
tumor protein p53 binding protein 1
VGNC:47720
478274
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor protein p53 binding protein 1
Macaque
tumor protein p53 binding protein 1
Mouse
Rat
Dog
tumor protein p53 binding protein 1
Protein Structure (21 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12888-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (77)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Gene Ontology Terms (27)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (619)
1 – 10 of 619
NUDT16L1
Tbio
Novelty: 0.05291665
p_int: 0.995455047
p_ni: 0.004544953
Score: 0.896
Data Source: BioPlex,STRINGDB
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.903890859
p_ni: 0.096109141
Score: 0.169
Data Source: BioPlex,STRINGDB
CDKN3
Tbio
Family: Enzyme
Novelty: 0.00093913
p_int: 0.897356315
p_ni: 0.102643685
Score: 0.447
Data Source: BioPlex,STRINGDB
THAP10
Tdark
Family: TF
Novelty: 1.06994665
p_int: 0.881744351
p_ni: 0.118255649
Score: 0.685
Data Source: BioPlex,STRINGDB
NUP50
Tbio
Novelty: 0.03424725
p_int: 0.770492151
p_ni: 0.229507849
Score: 0.271
Data Source: BioPlex,STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.999
Data Source: Reactome,STRINGDB
CHEK2
Tchem
Family: Kinase
Novelty: 0.00068355
Score: 0.998
Data Source: Reactome,STRINGDB
MDC1
Tbio
Novelty: 0.00533097
Score: 0.998
Data Source: Reactome,STRINGDB
XRCC6
Tbio
Novelty: 0.00127955
Score: 0.997
Data Source: Reactome,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  821.73

PubMed score by year
PubTator Score  343.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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