You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FAP
Prolyl endopeptidase FAP

Protein Summary
Description
Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000188790
  • ENSP00000188790
  • ENSG00000078098

Symbol
  • FAPA
  • SIMP
  • DPPIV
  • FAPalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.91
molecular function
0.86
biological term
0.7
PubMedID
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.99   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 582   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.99   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 582   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
linagliptin
chemical structure image
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.3
36.8
1
1
0
1.2
26.9
lymphocyte count
2
1
2
19.5
eosinophil count
2
1
2
18
adrenomedullin measurement
1
1
1
16.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
36.8
0
1.2
26.9
lymphocyte count
2
19.5
eosinophil count
2
18
adrenomedullin measurement
1
16.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast activation protein alpha
VGNC:425
459691
Macaque
fibroblast activation protein alpha
701541
Mouse
MGI:109608
14089
Dog
fibroblast activation protein alpha
VGNC:40727
608176
Horse
fibroblast activation protein alpha
VGNC:17908
100051480
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast activation protein alpha
Macaque
fibroblast activation protein alpha
Mouse
Dog
fibroblast activation protein alpha
Horse
fibroblast activation protein alpha
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12884-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (37)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (48)
1 – 10 of 48
GCG
Tchem
Novelty: 0.00004879
Score: 0.779
Data Source: STRINGDB
DPP7
Tchem
Family: Enzyme
Novelty: 0.00644738
Score: 0.745
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.741
Data Source: STRINGDB
PREP
Tchem
Family: Enzyme
Novelty: 0.00148266
Score: 0.718
Data Source: STRINGDB
GIP
Tchem
Novelty: 0.0007219
Score: 0.712
Data Source: STRINGDB
POSTN
Tbio
Novelty: 0.00108629
Score: 0.668
Data Source: STRINGDB
PYY
Tbio
Novelty: 0.00060997
Score: 0.663
Data Source: STRINGDB
LOX
Tbio
Family: Enzyme
Novelty: 0.000273
Score: 0.632
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.63
Data Source: STRINGDB
NAGLU
Tbio
Family: Enzyme
Novelty: 0.01033079
Score: 0.62
Data Source: STRINGDB
Publication Statistics
PubMed Score  367.99

PubMed score by year
PubTator Score  307.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: