You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FAP
Prolyl endopeptidase FAP

Protein Summary
Description
Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000188790
  • ENSP00000188790
  • ENSG00000078098

Symbol
  • FAPA
  • SIMP
  • DPPIV
  • FAPalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.91
molecular function
0.86
biological term
0.7
PubMedID
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.2   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 582   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.2   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 582   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
linagliptin
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (37)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (48)
1 – 10 of 48
GCG
Tchem
Novelty: 0.00005614
Score: 0.779
Data Source: STRINGDB
DPP7
Tchem
Family: Enzyme
Novelty: 0.00564941
Score: 0.745
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.0000437
Score: 0.741
Data Source: STRINGDB
PREP
Tchem
Family: Enzyme
Novelty: 0.0017302
Score: 0.718
Data Source: STRINGDB
GIP
Tchem
Novelty: 0.00089192
Score: 0.712
Data Source: STRINGDB
POSTN
Tbio
Novelty: 0.00123712
Score: 0.668
Data Source: STRINGDB
PYY
Tbio
Novelty: 0.0007798
Score: 0.663
Data Source: STRINGDB
LOX
Tbio
Family: Enzyme
Novelty: 0.0003871
Score: 0.632
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00057274
Score: 0.63
Data Source: STRINGDB
NAGLU
Tbio
Family: Enzyme
Novelty: 0.00623735
Score: 0.62
Data Source: STRINGDB
Publication Statistics
PubMed Score  241.20

PubMed score by year
PubTator Score  307.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: