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Tclin
GRIN2A
Glutamate receptor ionotropic, NMDA 2A

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are bo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330684
  • ENSP00000332549
  • ENSG00000183454
  • ENST00000396573
  • ENSP00000379818
  • ENST00000562109
  • ENSP00000454998

Symbol
  • NMDAR2A
  • LKS
  • EPND
  • FESD
  • NR2A
  • GluN2A
  • NMDAR2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
trait
0.97
ligand (chemical)
0.94
biological process
0.86
gene perturbation
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1583.81   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 715   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1583.81   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 715   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Active Ligands (1)
1 – 1 of 1
TCN-201
chemical structure image
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3
2
1.1
95.7
smoking status measurement
2
1
2
88.8
8
4
1
1.1
86.6
mathematical ability
2
2
2
81.3
intelligence
2
3
1
5.7
79.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
1.1
95.7
smoking status measurement
2
88.8
1
1.1
86.6
mathematical ability
2
81.3
intelligence
1
5.7
79.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor NMDA type subunit 2A
VGNC:8981
454396
Macaque
glutamate ionotropic receptor NMDA type subunit 2A
100429880
Mouse
MGI:95820
14811
Rat
RGD:2737
24409
Dog
glutamate ionotropic receptor NMDA type subunit 2A
VGNC:41492
490012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor NMDA type subunit 2A
Macaque
glutamate ionotropic receptor NMDA type subunit 2A
Mouse
Rat
Dog
glutamate ionotropic receptor NMDA type subunit 2A
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12879-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (76)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Long-term potentiation
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Gene expression (Transcription)
Generic Transcription Pathway
Long-term potentiation
Gene Ontology Terms (46)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (298)
1 – 10 of 298
GRIN2B
Tclin
Family: IC
Novelty: 0.00035058
p_int: 0.999999794
p_wrong: 2.06e-7
Score: 0.937
Data Source: BioPlex,Reactome,STRINGDB
PPP2R5B
Tbio
Family: Enzyme
Novelty: 0.08980945
p_int: 0.99999844
p_ni: 0.00000156
Data Source: BioPlex
LY6D
Tbio
Novelty: 0.07032941
p_int: 0.999987462
p_ni: 0.000012538
Data Source: BioPlex
PPP2R5E
Tbio
Family: Enzyme
Novelty: 0.05974697
p_int: 0.999829049
p_ni: 0.000170951
Data Source: BioPlex
TAP2
Tbio
Novelty: 0.0390555
p_int: 0.998796151
p_ni: 0.001201232
p_wrong: 0.000002617
Data Source: BioPlex
SMPD2
Tchem
Family: Enzyme
Novelty: 0.00375744
p_int: 0.99868335
p_ni: 0.001316601
p_wrong: 4.8e-8
Data Source: BioPlex
ATP5MC1
Tbio
Family: Enzyme
Novelty: 0.03538978
p_int: 0.99713793
p_ni: 0.002853397
p_wrong: 0.000008674
Data Source: BioPlex
TTC28
Tdark
Novelty: 0.16651519
p_int: 0.996911335
p_ni: 0.003088635
p_wrong: 3e-8
Data Source: BioPlex
NEURL4
Tdark
Novelty: 0.20430708
p_int: 0.996248762
p_ni: 0.003751238
Data Source: BioPlex
DNAJC18
Tdark
Novelty: 1.38573997
p_int: 0.995681423
p_ni: 0.004318577
Data Source: BioPlex
Publication Statistics
PubMed Score  1583.81

PubMed score by year
PubTator Score  508.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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