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Tbio
CHD3
Chromodomain-helicase-DNA-binding protein 3

Protein Summary
Description
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330494
  • ENSP00000332628
  • ENSG00000170004
  • ENST00000358181
  • ENSP00000350907
  • ENST00000380358
  • ENSP00000369716

Symbol
  • ZFH
  • Mi-2a
  • SNIBCPS
  • Mi2-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
interacting protein
0.99
hub protein
0.97
co-expressed gene
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.11   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.11   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
5
95.7
hematocrit
2
2
2
88.2
eosinophil count
3
1
3
85.7
hemoglobin measurement
3
2
3
84.2
neutrophil count
1
2
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
95.7
hematocrit
2
88.2
eosinophil count
3
85.7
hemoglobin measurement
3
84.2
neutrophil count
2
83.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 3
VGNC:9234
455278
Macaque
chromodomain helicase DNA binding protein 3
716508
Mouse
MGI:1344395
216848
Rat
RGD:1311923
303241
Dog
chromodomain helicase DNA binding protein 3
VGNC:39201
479489
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 3
Macaque
chromodomain helicase DNA binding protein 3
Mouse
Rat
Dog
chromodomain helicase DNA binding protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q12873-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (33)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (256)
1 – 10 of 256
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.999997396
p_ni:  0.000002603
Score:  0.998
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999994052
p_ni:  0.000005948
Score:  0.996
Data Source:  BioPlex,STRINGDB
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.999986549
p_ni:  0.000013451
Data Source:  BioPlex
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.99998605
p_ni:  0.00001395
Score:  0.828
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.999984839
p_ni:  0.000015161
Score:  0.482
Data Source:  BioPlex,STRINGDB
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999978577
p_ni:  0.000021423
Score:  0.864
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999957941
p_ni:  0.000042059
Score:  0.997
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999956725
p_ni:  0.000043272
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
p_int:  0.999639604
p_ni:  0.000360396
Score:  0.662
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.999267619
p_ni:  0.000732381
Score:  0.85
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  151.11

PubMed score by year
PubTator Score  87.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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