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Tbio
TCF15
Transcription factor 15

Protein Summary
Description
May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm. The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246080
  • ENSP00000246080
  • ENSG00000125878

Symbol
  • BHLHA40
  • BHLHEC2
  • EC2
  • PARAXIS
  • bHLHa40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
gene perturbation
0.61
PubMedID
0.61
transcription factor
0.61
disease perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 889.4   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 889.4   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
0.6
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (48)
1 – 10 of 48
MKX
Tbio
Novelty: 0.02160101
Score: 0.74
Data Source: STRINGDB
PAX1
Tbio
Family: TF
Novelty: 0.00618274
Score: 0.681
Data Source: STRINGDB
FOXC2
Tbio
Family: TF
Novelty: 0.00438844
Score: 0.654
Data Source: STRINGDB
DYNC1I2
Tbio
Novelty: 0.00228615
Score: 0.65
Data Source: STRINGDB
FOXC1
Tbio
Family: TF
Novelty: 0.00387011
Score: 0.587
Data Source: STRINGDB
HES5
Tbio
Family: TF
Novelty: 0.00565225
Score: 0.584
Data Source: STRINGDB
CDH17
Tbio
Novelty: 0.00035679
Score: 0.583
Data Source: STRINGDB
MEOX1
Tbio
Family: TF
Novelty: 0.02978667
Score: 0.569
Data Source: STRINGDB
JAG1
Tbio
Novelty: 0.00107618
Score: 0.569
Data Source: STRINGDB
FOXQ1
Tbio
Family: TF
Novelty: 0.01816638
Score: 0.559
Data Source: STRINGDB
Publication Statistics
PubMed Score  889.40

PubMed score by year
PubTator Score  82.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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