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Tchem
MERTK
Tyrosine-protein kinase Mer

Protein Summary
Description
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295408
  • ENSP00000295408
  • ENSG00000153208
  • ENST00000421804
  • ENSP00000389152

Symbol
  • MER
  • MER
  • RP38
  • c-Eyk
  • c-mer
  • Tyro12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
kinase perturbation
0.88
small molecule
0.85
biological process
0.84


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.17   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 780   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.17   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 780   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 129
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
90.8
2
2
0
1.1
63
hematocrit
1
1
1
61.4
aspartate aminotransferase measurement
2
2
1
6.1
60.8
neutrophil count
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
90.8
0
1.1
63
hematocrit
1
61.4
aspartate aminotransferase measurement
1
6.1
60.8
neutrophil count
1
58.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MER proto-oncogene, tyrosine kinase
VGNC:485
459492
Macaque
MER proto-oncogene, tyrosine kinase
698330
Mouse
MGI:96965
17289
Rat
RGD:69283
65037
Dog
MER proto-oncogene, tyrosine kinase
VGNC:43162
483060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MER proto-oncogene, tyrosine kinase
Macaque
MER proto-oncogene, tyrosine kinase
Mouse
Rat
Dog
MER proto-oncogene, tyrosine kinase
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12866-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (49)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (35)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
GAS6
Tbio
Novelty:  0.00297606
Score:  0.992
Data Source:  Reactome,STRINGDB
PROS1
Tbio
Novelty:  0.00275184
Score:  0.968
Data Source:  Reactome,STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.74
Data Source:  STRINGDB
TULP1
Tbio
Family:  TF
Novelty:  0.0192093
Score:  0.715
Data Source:  STRINGDB
RLBP1
Tbio
Novelty:  0.00526176
Score:  0.689
Data Source:  STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.683
Data Source:  STRINGDB
MFGE8
Tbio
Novelty:  0.00132919
Score:  0.681
Data Source:  STRINGDB
CRB1
Tbio
Novelty:  0.00560299
Score:  0.671
Data Source:  STRINGDB
MEGF10
Tbio
Novelty:  0.03039995
Score:  0.666
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.656
Data Source:  STRINGDB
Publication Statistics
PubMed Score  320.17

PubMed score by year
PubTator Score  151.36

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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