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Tbio
CNTN1
Contactin-1

Protein Summary
Description
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347616
  • ENSP00000325660
  • ENSG00000018236
  • ENST00000348761
  • ENSP00000261160
  • ENST00000547702
  • ENSP00000448004
  • ENST00000547849
  • ENSP00000448653
  • ENST00000551295
  • ENSP00000447006

Symbol
  • F3
  • GP135
  • MYPCN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
protein domain
0.85
virus perturbation
0.83
kinase perturbation
0.81
tissue sample
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.97   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.97   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.7
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.7
88.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
contactin 1
VGNC:5342
451836
Macaque
contactin 1
574365
Mouse
MGI:105980
12805
Rat
RGD:621300
117258
Dog
contactin 1
VGNC:39432
477641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
contactin 1
Macaque
contactin 1
Mouse
Rat
Dog
contactin 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12860-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
NOTCH2 Activation and Transmission of Signal to the Nucleus
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Axon guidance
Developmental Biology
L1CAM interactions
NOTCH2 Activation and Transmission of Signal to the Nucleus
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (107)
1 – 10 of 107
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.99841893
p_ni: 0.00158107
Data Source: BioPlex
MCAM
Tbio
Novelty: 0.00128524
p_int: 0.997079633
p_ni: 0.002920367
Score: 0.21
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.990598301
p_ni: 0.009401699
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.99044656
p_ni: 0.00955344
Data Source: BioPlex
PCDHGC3
Tbio
Novelty: 0.07203024
p_int: 0.989371513
p_ni: 0.010628487
Score: 0.274
Data Source: BioPlex,STRINGDB
SIGLECL1
Tdark
p_int: 0.974996411
p_ni: 0.025003589
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.966044679
p_ni: 0.033955321
Data Source: BioPlex
CEACAM21
Tdark
Novelty: 0.46116153
p_int: 0.903576581
p_ni: 0.096337809
p_wrong: 0.00008561
Data Source: BioPlex
HOXB5
Tbio
Family: TF
Novelty: 0.01119871
p_int: 0.900760812
p_ni: 0.09910728
p_wrong: 0.000131909
Data Source: BioPlex
CCNL2
Tbio
Novelty: 0.03667817
p_int: 0.894749351
p_ni: 0.105112762
p_wrong: 0.000137887
Data Source: BioPlex
Publication Statistics
PubMed Score  143.97

PubMed score by year
PubTator Score  60.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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