NFIA
Nuclear factor 1 A-type
Protein Summary
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- ENST00000371187
- ENSP00000360229
- ENSG00000162599
- ENST00000371189
- ENSP00000360231
- ENST00000403491
- ENSP00000384523
- ENST00000407417
- ENSP00000384680
- KIAA1439
- CTF
- NF1-A
- NFI-A
- NFI-L
- BRMUTD
- NF-I/A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.96 | ||
transcription factor | 0.96 | ||
kinase perturbation | 0.88 | ||
PubMedID | 0.87 | ||
transcription factor binding site profile | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 164.66 (req: < 5)
Gene RIFs: 48 (req: <= 3)
Antibodies: 235 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 164.66 (req: >= 5)
Gene RIFs: 48 (req: > 3)
Antibodies: 235 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0