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Tchem
MAP3K12
Mitogen-activated protein kinase kinase kinase 12

Protein Summary
Description
Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267079
  • ENSP00000267079
  • ENSG00000139625
  • ENST00000547035
  • ENSP00000448689
  • ENST00000547488
  • ENSP00000449038

Symbol
  • ZPK
  • DLK
  • MUK
  • ZPK
  • ZPKP1
  • MEKK12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.95
disease perturbation
0.87
protein domain
0.85
transcription factor binding site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.93   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.93   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 381
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (381)
1 – 10 of 381
CHEMBL1230609
chemical structure image
CHEMBL3733255
chemical structure image
CHEMBL3729943
chemical structure image
CHEMBL3730808
chemical structure image
CHEMBL3729085
chemical structure image
CHEMBL3732707
chemical structure image
CHEMBL3732966
chemical structure image
GNE-3511
chemical structure image
CHEMBL290352
chemical structure image
compound 11 [PMID: 26431428]
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
21.6
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (34)
1 – 10 of 34
MAP2K4
Tchem
Family: Kinase
Novelty: 0.00252847
Score: 0.949
Data Source: STRINGDB
MAP2K7
Tchem
Family: Kinase
Novelty: 0.00916401
Score: 0.945
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.919
Data Source: STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.917
Data Source: STRINGDB
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
Score: 0.902
Data Source: STRINGDB
PAK2
Tchem
Family: Kinase
Novelty: 0.0149123
Score: 0.902
Data Source: STRINGDB
TARS
Tchem
Family: Enzyme
Novelty: 0.00795387
Score: 0.803
Data Source: STRINGDB
MAPK8IP1
Tbio
Family: Enzyme
Novelty: 0.00284875
Score: 0.779
Data Source: STRINGDB
MBIP
Tbio
Novelty: 0.05807454
Score: 0.769
Data Source: STRINGDB
TARS2
Tbio
Family: Enzyme
Novelty: 0.01414012
Score: 0.745
Data Source: STRINGDB
Publication Statistics
PubMed Score  153.93

PubMed score by year
PubTator Score  92.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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