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Tbio
GRSF1
G-rich sequence factor 1

Protein Summary
Description
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254799
  • ENSP00000254799
  • ENSG00000132463
  • ENST00000502323
  • ENSP00000425430
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
interacting protein
0.89
transcription factor binding site profile
0.88
PubMedID
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.81   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.81   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
46.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
46.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G-rich RNA sequence binding factor 1
VGNC:10865
471208
Macaque
G-rich RNA sequence binding factor 1
706301
Mouse
MGI:106479
231413
Rat
RGD:1310858
305256
Dog
G-rich RNA sequence binding factor 1
VGNC:51773
475170
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G-rich RNA sequence binding factor 1
Macaque
G-rich RNA sequence binding factor 1
Mouse
Rat
Dog
G-rich RNA sequence binding factor 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12849-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Influenza Infection
Reactome
Influenza Life Cycle
Reactome
Influenza Viral RNA Transcription and Replication
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Influenza Infection
Influenza Life Cycle
Influenza Viral RNA Transcription and Replication
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (70)
1 – 10 of 70
IGHMBP2
Tbio
Novelty: 0.01054517
p_int: 0.806889174
p_ni: 0.193110826
Score: 0.634
Data Source: BioPlex,STRINGDB
ZNF777
Tdark
Family: TF
Novelty: 1.20195224
p_int: 0.780509398
p_ni: 0.219490602
Data Source: BioPlex
GPX4
Tbio
Family: Enzyme
Novelty: 0.00188213
Score: 0.985
Data Source: STRINGDB
DHX30
Tbio
Family: Enzyme
Novelty: 0.09152861
Score: 0.784
Data Source: STRINGDB
DDX28
Tbio
Family: Enzyme
Novelty: 0.16760542
Score: 0.757
Data Source: STRINGDB
PTCD3
Tbio
Novelty: 0.12368434
Score: 0.724
Data Source: STRINGDB
RMND1
Tbio
Novelty: 0.06181833
Score: 0.714
Data Source: STRINGDB
TRMT10C
Tbio
Family: Enzyme
Novelty: 0.07045719
Score: 0.677
Data Source: STRINGDB
PTCD1
Tdark
Novelty: 0.17182155
Score: 0.665
Data Source: STRINGDB
FASTKD2
Tbio
Family: Enzyme
Novelty: 0.12614412
Score: 0.648
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.81

PubMed score by year
PubTator Score  13.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer