Tbio STX4 Syntaxin-4

Protein Summary

Description

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Uniprot Accession IDs

• Q12846
• A8MXY0
• Q15525
• Q6FHE8

Gene Name

• STX4

Ensembl ID

• ENST00000313843
• ENSP00000317714
• ENSG00000103496
• ENST00000394998
• ENSP00000378447

Symbol

• STX4A
• STX4A
• p35-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
biological process	0.96
disease perturbation	0.95
histone modification site profile	0.93
protein complex	0.87

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-4

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.71   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.71   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (170)

Explore Interacting Targets

1 – 10 of 170

• See Interactions on String-DB

STXBP3

Tbio

Novelty:  0.03346737

p_int:  0.999997247

p_ni:  0.000002753

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

VAMP5

Tbio

Novelty:  0.09958312

p_int:  0.999582298

p_ni:  0.000417702

Score:  0.861

Data Source:  BioPlex,STRINGDB

STXBP6

Tbio

Novelty:  0.13195671

p_int:  0.999062595

p_ni:  0.000937404

Score:  0.942

Data Source:  BioPlex,STRINGDB

ASPH

Tchem

Family:  Enzyme

Novelty:  0.00291455

p_int:  0.997141552

p_ni:  0.00285842

p_wrong:  2.8e-8

Score:  0.161

Data Source:  BioPlex,STRINGDB

AAGAB

Tbio

Novelty:  0.0479209

p_int:  0.996953129

p_ni:  0.003046871

Score:  0.186

Data Source:  BioPlex,STRINGDB

PLPPR1

Tdark

Family:  Enzyme

Novelty:  0.38109551

p_int:  0.99555394

p_ni:  0.00444606

Score:  0.55

Data Source:  BioPlex,STRINGDB

SLC7A1

Tbio

Family:  Transporter

Novelty:  0.00197313

p_int:  0.993641817

p_ni:  0.006358183

Data Source:  BioPlex

STX7

Tbio

Novelty:  0.03109969

p_int:  0.99316654

p_ni:  0.006833427

p_wrong:  3.3e-8

Score:  0.865

Data Source:  BioPlex,STRINGDB

STX6

Tbio

Novelty:  0.01494028

p_int:  0.982736986

p_ni:  0.017260644

p_wrong:  0.00000237

Score:  0.99

Data Source:  BioPlex,STRINGDB

TMEM30B

Tbio

Novelty:  0.26735006

p_int:  0.978332813

p_ni:  0.021667187

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (166)

Reactome (16)

KEGG (2)

PathwayCommons (5)

WikiPathways (143)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Disinhibition of SNARE formation	5 targets	R-HSA-114516

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Disinhibition of SNARE formation	5 targets	R-HSA-114516

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (56)

Functions (3)

Components (29)

Processes (24)

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1 – 3 of 3

GO Term	Evidence	Assigned by
sphingomyelin phosphodiesterase activator activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
SNAP receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
SNARE binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (43)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 43

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
psoriasis	EFO_0000676	3	3	0	1.2	93.1
response to anticoagulant	GO_0061476	1	1	0	20.4	91.9
triglyceride measurement	EFO_0004530	5	4	5		87.4
Parkinson disease	MONDO_0005180	3	2	1	1.1	86.5
body mass index	EFO_0004340	5	2	6		85

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
psoriasis	EFO_0000676	0	1.2	93.1
response to anticoagulant	GO_0061476	0	20.4	91.9
triglyceride measurement	EFO_0004530	5		87.4
Parkinson disease	MONDO_0005180	1	1.1	86.5
body mass index	EFO_0004340	6		85

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Coiled coil
Complete proteome
Membrane
Neurotransmitter transport
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
Agents acting on the renin-angiotensin system use measurement
Alzheimer disease
basophil percentage of leukocytes
bilirubin measurement
body fat distribution
body fat percentage
body height
body mass index
brain measurement
central corneal thickness

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	syntaxin 4A (placental)	MGI:893577	20909
Rat	syntaxin 4	RGD:621019	81803
Dog	syntaxin 4	VGNC:46956	489919
Horse	syntaxin 4	VGNC:23731	100063460
Cow	syntaxin 4	VGNC:35440	508675

Species	Name	OMA	EggNOG	Inparanoid
Mouse	syntaxin 4A (placental)
Rat	syntaxin 4
Dog	syntaxin 4
Horse	syntaxin 4
Cow	syntaxin 4

Publication Statistics

PubMed Score 127.71

PubMed score by year

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PubTator Score 82.46

PubTator score by year

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Related Publications

Text Mined References (73)

GeneRif Annotations (20)

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PMID	Year	Title