Protein Classes
Protein Summary
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
- ENST00000313843
- ENSP00000317714
- ENSG00000103496
- ENST00000394998
- ENSP00000378447
- STX4A
- STX4A
- p35-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.97 | ||
biological process | 0.96 | ||
disease perturbation | 0.95 | ||
histone modification site profile | 0.93 | ||
protein complex | 0.87 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.09 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 261 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.09 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 261 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 2 | 1 | 2 | 86.1 | |||||
snoring measurement | 1 | 1 | 0 | 1 | 62.4 | ||||
triglyceride measurement | 1 | 1 | 1 | 35.4 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 2 | 86.1 | |||||
snoring measurement | 0 | 1 | 62.4 | ||||
triglyceride measurement | 1 | 35.4 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:893577 | 20909 | ||||||
Rat | RGD:621019 | 81803 | ||||||
Dog | syntaxin 4 | VGNC:46956 | 489919 | |||||
Horse | syntaxin 4 | VGNC:23731 | 100063460 | |||||
Cow | syntaxin 4 | VGNC:35440 | 508675 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | syntaxin 4 | |||||
Horse | syntaxin 4 | |||||
Cow | syntaxin 4 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (166)
Reactome (16)
KEGG (2)
PathwayCommons (5)
WikiPathways (143)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 16
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disinhibition of SNARE formation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Cytokine Signaling in Immune system | ||||
Disinhibition of SNARE formation | ||||
Gene Ontology Terms (56)
Functions (3)
Components (29)
Processes (24)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (170)
1 – 10 of 170
STXBP3
Novelty: 0.03346737
p_int: 0.999997247
p_ni: 0.000002753
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VAMP5
Novelty: 0.09958312
p_int: 0.999582298
p_ni: 0.000417702
Score: 0.861
Data Source: BioPlex,STRINGDB
STXBP6
Novelty: 0.13195671
p_int: 0.999062595
p_ni: 0.000937404
Score: 0.942
Data Source: BioPlex,STRINGDB
ASPH
Family: Enzyme
Novelty: 0.00291455
p_int: 0.997141552
p_ni: 0.00285842
p_wrong: 2.8e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
AAGAB
Novelty: 0.0479209
p_int: 0.996953129
p_ni: 0.003046871
Score: 0.186
Data Source: BioPlex,STRINGDB
PLPPR1
Family: Enzyme
Novelty: 0.38109551
p_int: 0.99555394
p_ni: 0.00444606
Score: 0.55
Data Source: BioPlex,STRINGDB
SLC7A1
Family: Transporter
Novelty: 0.00197313
p_int: 0.993641817
p_ni: 0.006358183
Data Source: BioPlex
STX7
Novelty: 0.03109969
p_int: 0.99316654
p_ni: 0.006833427
p_wrong: 3.3e-8
Score: 0.865
Data Source: BioPlex,STRINGDB
STX6
Novelty: 0.01494028
p_int: 0.982736986
p_ni: 0.017260644
p_wrong: 0.00000237
Score: 0.99
Data Source: BioPlex,STRINGDB
TMEM30B
Novelty: 0.26735006
p_int: 0.978332813
p_ni: 0.021667187
Data Source: BioPlex
Publication Statistics
PubMed Score 111.09
PubMed score by year
PubTator Score 82.46
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword