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Tbio
STX4
Syntaxin-4

Protein Summary
Description
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313843
  • ENSP00000317714
  • ENSG00000103496
  • ENST00000394998
  • ENSP00000378447

Symbol
  • STX4A
  • STX4A
  • p35-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
biological process
0.96
disease perturbation
0.95
histone modification site profile
0.93
protein complex
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.09   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.09   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
86.1
snoring measurement
1
1
0
1
62.4
triglyceride measurement
1
1
1
35.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
86.1
snoring measurement
0
1
62.4
triglyceride measurement
1
35.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:893577
20909
Rat
RGD:621019
81803
Dog
syntaxin 4
VGNC:46956
489919
Horse
syntaxin 4
VGNC:23731
100063460
Cow
syntaxin 4
VGNC:35440
508675
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
syntaxin 4
Horse
syntaxin 4
Cow
syntaxin 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q12846-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (166)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Reactome
Disinhibition of SNARE formation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Disinhibition of SNARE formation
Protein-Protein Interactions (170)
1 – 10 of 170
STXBP3
Tbio
Novelty: 0.03346737
p_int: 0.999997247
p_ni: 0.000002753
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VAMP5
Tbio
Novelty: 0.09958312
p_int: 0.999582298
p_ni: 0.000417702
Score: 0.861
Data Source: BioPlex,STRINGDB
STXBP6
Tbio
Novelty: 0.13195671
p_int: 0.999062595
p_ni: 0.000937404
Score: 0.942
Data Source: BioPlex,STRINGDB
ASPH
Tbio
Family: Enzyme
Novelty: 0.00291455
p_int: 0.997141552
p_ni: 0.00285842
p_wrong: 2.8e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
AAGAB
Tbio
Novelty: 0.0479209
p_int: 0.996953129
p_ni: 0.003046871
Score: 0.186
Data Source: BioPlex,STRINGDB
PLPPR1
Tdark
Family: Enzyme
Novelty: 0.38109551
p_int: 0.99555394
p_ni: 0.00444606
Score: 0.55
Data Source: BioPlex,STRINGDB
SLC7A1
Tbio
Family: Transporter
Novelty: 0.00197313
p_int: 0.993641817
p_ni: 0.006358183
Data Source: BioPlex
STX7
Tbio
Novelty: 0.03109969
p_int: 0.99316654
p_ni: 0.006833427
p_wrong: 3.3e-8
Score: 0.865
Data Source: BioPlex,STRINGDB
STX6
Tbio
Novelty: 0.01494028
p_int: 0.982736986
p_ni: 0.017260644
p_wrong: 0.00000237
Score: 0.99
Data Source: BioPlex,STRINGDB
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.978332813
p_ni: 0.021667187
Data Source: BioPlex
Publication Statistics
PubMed Score  111.09

PubMed score by year
PubTator Score  82.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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