Pharos : Target Details

Tbio

Protein Summary

Description

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Uniprot Accession IDs

Gene Name

STX4

Ensembl ID

ENST00000313843
ENSP00000317714
ENSG00000103496
ENST00000394998
ENSP00000378447

Symbol

STX4A
STX4A
p35-2

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97

biological process	0.96

disease perturbation	0.95

histone modification site profile	0.93

protein complex	0.87

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.95 (req: < 5)

View Publications

Gene RIFs: 20 (req: <= 3)

View Gene RIFs

Antibodies: 261 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.95 (req: >= 5)

Gene RIFs: 20 (req: > 3)

Antibodies: 261 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Protein-Protein Interactions (170)

1 – 10 of 170

See Interactions on String-DB

STXBP3

Tbio

Novelty: 0.03346737

p_int: 0.999997247

p_ni: 0.000002753

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

VAMP5

Tbio

Novelty: 0.09958312

p_int: 0.999582298

p_ni: 0.000417702

Score: 0.861

Data Source: BioPlex,STRINGDB

STXBP6

Tbio

Novelty: 0.13195671

p_int: 0.999062595

p_ni: 0.000937404

Score: 0.942

Data Source: BioPlex,STRINGDB

ASPH

Tbio

Family: Enzyme

Novelty: 0.00291455

p_int: 0.997141552

p_ni: 0.00285842

p_wrong: 2.8e-8

Score: 0.161

Data Source: BioPlex,STRINGDB

AAGAB

Tbio

Novelty: 0.0479209

p_int: 0.996953129

p_ni: 0.003046871

Score: 0.186

Data Source: BioPlex,STRINGDB

PLPPR1

Tdark

Family: Enzyme

Novelty: 0.38109551

p_int: 0.99555394

p_ni: 0.00444606

Score: 0.55

Data Source: BioPlex,STRINGDB

SLC7A1

Tbio

Family: Transporter

Novelty: 0.00197313

p_int: 0.993641817

p_ni: 0.006358183

Data Source: BioPlex

STX7

Tbio

Novelty: 0.03109969

p_int: 0.99316654

p_ni: 0.006833427

p_wrong: 3.3e-8

Score: 0.865

Data Source: BioPlex,STRINGDB

STX6

Tbio

Novelty: 0.01494028

p_int: 0.982736986

p_ni: 0.017260644

p_wrong: 0.00000237

Score: 0.99

Data Source: BioPlex,STRINGDB

TMEM30B

Tbio

Novelty: 0.26735006

p_int: 0.978332813

p_ni: 0.021667187

Data Source: BioPlex

Pathways (166)

Reactome (16)

KEGG (2)

PathwayCommons (5)

WikiPathways (143)

Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 16

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218

Reactome	Antigen processing-Cross presentation	169 targets	R-HSA-1236975

Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169

Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	Disinhibition of SNARE formation	5 targets	R-HSA-114516

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218

Antigen processing-Cross presentation	169 targets	R-HSA-1236975

Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169

Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Disinhibition of SNARE formation	5 targets	R-HSA-114516

Gene Ontology Terms (56)

Functions (3)

Components (29)

Processes (24)

Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
sphingomyelin phosphodiesterase activator activity	Inferred from Mutant Phenotype (IMP)	UniProtKB

SNAP receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

SNARE binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

GWAS Traits (31)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 31

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
mean reticulocyte volume	EFO_0010701	1	1	1		82.8

mean corpuscular volume	EFO_0004526	1	1	1		82.2

response to anticoagulant	GO_0061476	1	1	0	20.4	81

psoriasis	EFO_0000676	3	3	0	1.2	80.2

triglyceride measurement	EFO_0004530	3	3	3		72.3

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 31

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
mean reticulocyte volume	EFO_0010701	1		82.8

mean corpuscular volume	EFO_0004526	1		82.2

response to anticoagulant	GO_0061476	0	20.4	81

psoriasis	EFO_0000676	0	1.2	80.2

triglyceride measurement	EFO_0004530	3		72.3

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

No Header	No Header
Alternative splicing

Cell membrane

Coiled coil

Complete proteome

Membrane

Neurotransmitter transport

Phosphoprotein

Reference proteome

Transmembrane

Transmembrane helix

GWAS Trait

No Header	No Header
Alzheimer's disease

basophil percentage of leukocytes

body fat distribution

body height

body mass index

family history of Alzheimerâs disease

feeling tense measurement

gait measurement

hematocrit

hip circumference

MGI Phenotype

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Mouse	syntaxin 4A (placental)	MGI:893577	20909

Rat	syntaxin 4	RGD:621019	81803

Dog	syntaxin 4	VGNC:46956	489919

Horse	syntaxin 4	VGNC:23731	100063460

Cow	syntaxin 4	VGNC:35440	508675

Species	Name	OMA	EggNOG	Inparanoid
Mouse	syntaxin 4A (placental)

Rat	syntaxin 4

Dog	syntaxin 4

Horse	syntaxin 4

Cow	syntaxin 4

Publication Statistics

PubMed Score 114.95

PubMed score by year

PubTator Score 82.46

PubTator score by year