Protein Summary
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
- ENST00000313843
- ENSP00000317714
- ENSG00000103496
- ENST00000394998
- ENSP00000378447
- STX4A
- STX4A
- p35-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.97 | ||
biological process | 0.96 | ||
disease perturbation | 0.95 | ||
histone modification site profile | 0.93 | ||
protein complex | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.95 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 261 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.95 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 261 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (170)
STXBP3
Novelty: 0.03346737
p_int: 0.999997247
p_ni: 0.000002753
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VAMP5
Novelty: 0.09958312
p_int: 0.999582298
p_ni: 0.000417702
Score: 0.861
Data Source: BioPlex,STRINGDB
STXBP6
Novelty: 0.13195671
p_int: 0.999062595
p_ni: 0.000937404
Score: 0.942
Data Source: BioPlex,STRINGDB
ASPH
Family: Enzyme
Novelty: 0.00291455
p_int: 0.997141552
p_ni: 0.00285842
p_wrong: 2.8e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
AAGAB
Novelty: 0.0479209
p_int: 0.996953129
p_ni: 0.003046871
Score: 0.186
Data Source: BioPlex,STRINGDB
PLPPR1
Family: Enzyme
Novelty: 0.38109551
p_int: 0.99555394
p_ni: 0.00444606
Score: 0.55
Data Source: BioPlex,STRINGDB
SLC7A1
Family: Transporter
Novelty: 0.00197313
p_int: 0.993641817
p_ni: 0.006358183
Data Source: BioPlex
STX7
Novelty: 0.03109969
p_int: 0.99316654
p_ni: 0.006833427
p_wrong: 3.3e-8
Score: 0.865
Data Source: BioPlex,STRINGDB
STX6
Novelty: 0.01494028
p_int: 0.982736986
p_ni: 0.017260644
p_wrong: 0.00000237
Score: 0.99
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (166)
Reactome (16)
KEGG (2)
PathwayCommons (5)
WikiPathways (143)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disinhibition of SNARE formation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Cytokine Signaling in Immune system | ||||
Disinhibition of SNARE formation | ||||
Viral Interactions (0)
Gene Ontology Terms (56)
Functions (3)
Components (29)
Processes (24)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (31)
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 1 | 1 | 82.8 | |||||
mean corpuscular volume | 1 | 1 | 1 | 82.2 | |||||
response to anticoagulant | 1 | 1 | 0 | 20.4 | 81 | ||||
3 | 3 | 0 | 1.2 | 80.2 | |||||
triglyceride measurement | 3 | 3 | 3 | 72.3 | |||||
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 82.8 | |||||
mean corpuscular volume | 1 | 82.2 | |||||
response to anticoagulant | 0 | 20.4 | 81 | ||||
0 | 1.2 | 80.2 | |||||
triglyceride measurement | 3 | 72.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:893577 | 20909 | ||||||
Rat | RGD:621019 | 81803 | ||||||
Dog | syntaxin 4 | VGNC:46956 | 489919 | |||||
Horse | syntaxin 4 | VGNC:23731 | 100063460 | |||||
Cow | syntaxin 4 | VGNC:35440 | 508675 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | syntaxin 4 | |||||
Horse | syntaxin 4 | |||||
Cow | syntaxin 4 | |||||
Publication Statistics
PubMed Score 114.95
PubMed score by year
PubTator Score 82.46
PubTator score by year
Related Publications
Text Mined References (73)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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