You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POU4F2
POU domain, class 4, transcription factor 2

Protein Summary
Description
Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281321
  • ENSP00000281321
  • ENSG00000151615

Symbol
  • BRN3B
  • BRN3B
  • BRN3.2
  • Brn-3b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
protein domain
0.85
biological process
0.84
PubMedID
0.63
phenotype
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.96   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.96   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Association with Co-factors
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Association with Co-factors
Gene Ontology Terms (48)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (83)
1 – 10 of 83
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.952
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.947
Data Source: Reactome,STRINGDB
ATOH7
Tbio
Family: TF
Novelty: 0.00536814
Score: 0.897
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.825
Data Source: STRINGDB
VSX2
Tbio
Family: TF
Novelty: 0.0046733
Score: 0.785
Data Source: STRINGDB
OPN4
Tbio
Family: GPCR
Novelty: 0.00105995
Score: 0.753
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.731
Data Source: STRINGDB
SEMA6D
Tbio
Novelty: 0.01322475
Score: 0.686
Data Source: STRINGDB
RIT2
Tbio
Family: Enzyme
Novelty: 0.01672192
Score: 0.641
Data Source: STRINGDB
TTC29
Tdark
Novelty: 0.1887357
Score: 0.62
Data Source: STRINGDB
Publication Statistics
PubMed Score  117.96

PubMed score by year
PubTator Score  44.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer