Tchem BPTF Nucleosome-remodeling factor subunit BPTF

Protein Summary

Description

Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q12830
• Q6NX67
• Q7Z7D6
• Q9UIG2

Gene Name

• BPTF

Ensembl ID

• ENST00000306378
• ENSP00000307208
• ENSG00000171634
• ENST00000321892
• ENSP00000315454

Symbol

• FAC1
• FALZ
• FAC1
• FALZ
• NEDDFL
• NURF301

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor perturbation	0.98
virus perturbation	0.96
microRNA	0.9
transcription factor binding site profile	0.89

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.23   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.23   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 35

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0