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Tchem
BPTF
Nucleosome-remodeling factor subunit BPTF

Protein Summary
Description
Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-term ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306378
  • ENSP00000307208
  • ENSG00000171634
  • ENST00000321892
  • ENSP00000315454

Symbol
  • FAC1
  • FALZ
  • FAC1
  • FALZ
  • NEDDFL
  • NURF301
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.98
virus perturbation
0.96
microRNA
0.9
transcription factor binding site profile
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.29   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.29   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (470)
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999803
p_ni:  1.97e-7
Score:  0.757
Data Source:  BioPlex,STRINGDB
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.999985977
p_ni:  0.000014023
Data Source:  BioPlex
RFXANK
Tbio
Novelty:  0.00355465
p_int:  0.999980123
p_ni:  0.000019877
Score:  0.352
Data Source:  BioPlex,STRINGDB
ZNF784
Tdark
Family:  TF
Novelty:  17.08860759
p_int:  0.995108181
p_ni:  0.004891819
Score:  0.185
Data Source:  BioPlex,STRINGDB
HSPB7
Tbio
Novelty:  0.03344805
p_int:  0.985321671
p_ni:  0.014678304
p_wrong:  2.5e-8
Score:  0.315
Data Source:  BioPlex,STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.944083967
p_ni:  0.055916006
p_wrong:  2.7e-8
Score:  0.184
Data Source:  BioPlex,STRINGDB
BUB1
Tchem
Family:  Kinase
Novelty:  0.00327514
p_int:  0.928582687
p_ni:  0.071417169
p_wrong:  1.44e-7
Score:  0.72
Data Source:  BioPlex,STRINGDB
SMARCA5
Tbio
Novelty:  0.00518484
Score:  0.997
Data Source:  STRINGDB
SMARCA1
Tbio
Novelty:  0.00452148
Score:  0.997
Data Source:  STRINGDB
HMGXB4
Tbio
Family:  TF
Novelty:  0.23456617
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
3
4
91.9
triglyceride measurement
3
3
3
88.4
3
3
2
1.1
87.6
serum gamma-glutamyl transferase measurement
2
2
2
83.9
eosinophil percentage of leukocytes
2
2
2
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.9
triglyceride measurement
3
88.4
2
1.1
87.6
serum gamma-glutamyl transferase measurement
2
83.9
eosinophil percentage of leukocytes
2
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain PHD finger transcription factor
VGNC:9224
454840
Macaque
bromodomain PHD finger transcription factor
718812
Mouse
MGI:2444008
207165
Dog
bromodomain PHD finger transcription factor
VGNC:38513
480467
Horse
bromodomain PHD finger transcription factor
VGNC:15874
100063881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain PHD finger transcription factor
Macaque
bromodomain PHD finger transcription factor
Mouse
Dog
bromodomain PHD finger transcription factor
Horse
bromodomain PHD finger transcription factor
Publication Statistics
PubMed Score 139.29
PubMed score by year
PubTator Score 47.84
PubTator score by year
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Related Publications
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PMID
Year
Title