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Tchem
BPTF
Nucleosome-remodeling factor subunit BPTF

Protein Summary
Description
Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-term ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306378
  • ENSP00000307208
  • ENSG00000171634
  • ENST00000321892
  • ENSP00000315454

Symbol
  • FAC1
  • FALZ
  • FAC1
  • FALZ
  • NEDDFL
  • NURF301
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.98
virus perturbation
0.96
microRNA
0.9
transcription factor binding site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.43   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.43   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3086885
chemical structure image
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1.1
95.1
body mass index
4
3
5
94.1
waist-hip ratio
2
1
2
88.8
visceral adipose tissue measurement
1
1
1
87.7
3
1
0
1.2
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
95.1
body mass index
5
94.1
waist-hip ratio
2
88.8
visceral adipose tissue measurement
1
87.7
0
1.2
81.6
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (470)
1 – 10 of 470
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999999803
p_ni: 1.97e-7
Score: 0.757
Data Source: BioPlex,STRINGDB
NUP62CL
Tdark
Novelty: 2.93223607
p_int: 0.999985977
p_ni: 0.000014023
Data Source: BioPlex
RFXANK
Tbio
Novelty: 0.00355465
p_int: 0.999980123
p_ni: 0.000019877
Score: 0.352
Data Source: BioPlex,STRINGDB
ZNF784
Tdark
Family: TF
Novelty: 17.08860759
p_int: 0.995108181
p_ni: 0.004891819
Score: 0.185
Data Source: BioPlex,STRINGDB
HSPB7
Tbio
Novelty: 0.03344805
p_int: 0.985321671
p_ni: 0.014678304
p_wrong: 2.5e-8
Score: 0.315
Data Source: BioPlex,STRINGDB
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.944083967
p_ni: 0.055916006
p_wrong: 2.7e-8
Score: 0.184
Data Source: BioPlex,STRINGDB
BUB1
Tchem
Family: Kinase
Novelty: 0.00327514
p_int: 0.928582687
p_ni: 0.071417169
p_wrong: 1.44e-7
Score: 0.72
Data Source: BioPlex,STRINGDB
SMARCA5
Tbio
Novelty: 0.00518484
Score: 0.997
Data Source: STRINGDB
SMARCA1
Tbio
Novelty: 0.00452148
Score: 0.997
Data Source: STRINGDB
HMGXB4
Tbio
Family: TF
Novelty: 0.23456617
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  132.43

PubMed score by year
PubTator Score  47.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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