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Tbio
RAB40B
Ras-related protein Rab-40B

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000571995
  • ENSP00000461785
  • ENSG00000141542

Symbol
  • SEC4L
  • RAR
  • SEC4L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
molecular function
0.9
transcription factor perturbation
0.88
histone modification site profile
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.06   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.06   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
13
14
19
99.6
heel bone mineral density
2
2
2
85.5
red blood cell distribution width
1
1
1
58.4
mean platelet volume
1
1
1
38.2
low density lipoprotein cholesterol measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
19
99.6
heel bone mineral density
2
85.5
red blood cell distribution width
1
58.4
mean platelet volume
1
38.2
low density lipoprotein cholesterol measurement
1
33.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB40B, member RAS oncogene family
VGNC:14188
454998
Macaque
RAB40B, member RAS oncogene family
719629
Mouse
MGI:2183451
217371
Rat
RGD:1305663
303754
Dog
RAB40B, member RAS oncogene family
608295
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB40B, member RAS oncogene family
Macaque
RAB40B, member RAS oncogene family
Mouse
Rat
Dog
RAB40B, member RAS oncogene family
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q12829-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (105)
1 – 10 of 105
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999999997
p_ni:  3e-9
Score:  0.791
Data Source:  BioPlex,STRINGDB
RAB40C
Tbio
Novelty:  0.09183134
p_int:  0.999999988
p_ni:  2e-9
p_wrong:  1e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.937
Data Source:  BioPlex,STRINGDB
RAB40AL
Tbio
Novelty:  0.00908832
p_int:  0.999999967
p_ni:  5e-9
p_wrong:  2.8e-8
Score:  0.875
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999994834
p_ni:  5e-9
p_wrong:  0.000005161
Data Source:  BioPlex
DCAF17
Tbio
Novelty:  0.04261326
p_int:  0.999994688
p_ni:  7.99e-7
p_wrong:  0.000004513
Score:  0.29
Data Source:  BioPlex,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
p_int:  0.990959475
p_ni:  0.009040525
Score:  0.891
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.990162391
p_ni:  0.009837605
p_wrong:  4e-9
Score:  0.622
Data Source:  BioPlex,STRINGDB
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
Score:  0.933
Data Source:  STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
Score:  0.932
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.06

PubMed score by year
PubTator Score  119.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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