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Tbio
TRO
Trophinin

Protein Summary
Description
Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000173898
  • ENSP00000173898
  • ENSG00000067445
  • ENST00000319167
  • ENSP00000318278
  • ENST00000375022
  • ENSP00000364162
  • ENST00000375041
  • ENSP00000364181
  • ENST00000399736
  • ENSP00000382641
  • ENST00000420798
  • ENSP00000405126

Symbol
  • KIAA1114
  • MAGED3
  • MAGED3
  • MAGE-d3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
tissue sample
0.69
transcription factor perturbation
0.68
cellular component
0.58
disease perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.44   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.44   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (39)
1 – 10 of 39
TCTEX1D4
Tbio
Novelty: 0.70588235
p_int: 0.999978926
p_ni: 0.000021074
Data Source: BioPlex
GNAS
Tbio
Novelty: 0.00259764
p_int: 0.999978679
p_ni: 0.00002132
p_wrong: 1e-9
Data Source: BioPlex
PPM1E
Tbio
Family: Enzyme
Novelty: 0.11538462
p_int: 0.999794474
p_ni: 0.000205526
Score: 0.201
Data Source: BioPlex,STRINGDB
MLF1
Tbio
Novelty: 0.02755445
p_int: 0.999383945
p_ni: 0.000616055
Data Source: BioPlex
NCAPH2
Tbio
Novelty: 0.16162826
p_int: 0.998721735
p_ni: 0.001278265
Data Source: BioPlex
DNAJB2
Tbio
Novelty: 0.06294878
p_int: 0.998582645
p_ni: 0.001403863
p_wrong: 0.000013492
Data Source: BioPlex
ARPC5
Tbio
Novelty: 0.08405086
p_int: 0.998405664
p_ni: 0.001594336
Data Source: BioPlex
RABGAP1L
Tbio
Family: Enzyme
Novelty: 0.369696
p_int: 0.993940861
p_ni: 0.005921401
p_wrong: 0.000137737
Score: 0.327
Data Source: BioPlex,STRINGDB
SPACA1
Tbio
Novelty: 0.14150943
p_int: 0.992448531
p_ni: 0.007183905
p_wrong: 0.000367564
Data Source: BioPlex
RPL28
Tbio
Novelty: 0.0322797
p_int: 0.991946577
p_ni: 0.007525539
p_wrong: 0.000527884
Data Source: BioPlex
Publication Statistics
PubMed Score  99.44

PubMed score by year
PubTator Score  36.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer