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Tclin
KCNH2
Potassium voltage-gated channel subfamily H member 2

Protein Summary
Description
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661). Isoform A-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Isoform B-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isof ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262186
  • ENSP00000262186
  • ENSG00000055118
  • ENST00000330883
  • ENSP00000328531

Symbol
  • ERG
  • ERG1
  • HERG
  • ERG1
  • HERG
  • LQT2
  • SQT1
  • ERG-1
  • H-ERG
  • HERG1
  • Kv11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
1
protein domain
1
drug
0.91
hub protein
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2924.25   (req: < 5)
Gene RIFs: 465   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2924.25   (req: >= 5)
Gene RIFs: 465   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6062
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 109