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Tchem
ASPH
Aspartyl/asparaginyl beta-hydroxylase

Protein Summary
Description
Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement facto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356457
  • ENSP00000348841
  • ENSG00000198363
  • ENST00000379449
  • ENSP00000368762
  • ENST00000379454
  • ENSP00000368767
  • ENST00000389204
  • ENSP00000373856
  • ENST00000445642
  • ENSP00000394013
  • ENST00000517847
  • ENSP00000429954
  • ENST00000517903
  • ENSP00000430245
  • ENST00000518068
  • ENSP00000429286
  • ENST00000522603
  • ENSP00000436188
  • ENST00000522835
  • ENSP00000429160
  • ENST00000541428
  • ENSP00000437864

Symbol
  • BAH
  • AAH
  • BAH
  • HAAH
  • JCTN
  • FDLAB
  • junctin
  • CASQ2BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
interacting protein
0.99
kinase perturbation
0.95
small molecule perturbation
0.88
transcription factor binding site profile
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.26   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.26   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1