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Tbio
ASPH
Aspartyl/asparaginyl beta-hydroxylase

Protein Summary
Description
Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement facto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356457
  • ENSP00000348841
  • ENSG00000198363
  • ENST00000379449
  • ENSP00000368762
  • ENST00000379454
  • ENSP00000368767
  • ENST00000389204
  • ENSP00000373856
  • ENST00000445642
  • ENSP00000394013
  • ENST00000517847
  • ENSP00000429954
  • ENST00000517903
  • ENSP00000430245
  • ENST00000518068
  • ENSP00000429286
  • ENST00000522603
  • ENSP00000436188
  • ENST00000522835
  • ENSP00000429160
  • ENST00000541428
  • ENSP00000437864

Symbol
  • BAH
  • AAH
  • BAH
  • HAAH
  • JCTN
  • FDLAB
  • junctin
  • CASQ2BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
interacting protein
0.99
kinase perturbation
0.95
small molecule perturbation
0.88
transcription factor binding site profile
0.88


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 348.91   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 348.91   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aspartate beta-hydroxylase
VGNC:3032
464202
Macaque
aspartate beta-hydroxylase
699884
Mouse
MGI:1914186
65973
Dog
aspartate beta-hydroxylase
VGNC:38186
403846
Horse
aspartate beta-hydroxylase
100065909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aspartate beta-hydroxylase
Macaque
aspartate beta-hydroxylase
Mouse
Dog
aspartate beta-hydroxylase
Horse
aspartate beta-hydroxylase
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12797-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Muscle contraction
Stimuli-sensing channels
Gene Ontology Terms (44)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (90)
1 – 10 of 90
MCUB
Tbio
Novelty: 0.0486243
p_int: 0.999999732
p_ni: 2.68e-7
Data Source: BioPlex
MCU
Tbio
Family: IC
Novelty: 0.00114914
p_int: 0.999997105
p_ni: 0.000002895
Score: 0.271
Data Source: BioPlex,STRINGDB
STEAP3
Tbio
Family: Enzyme
Novelty: 0.02042104
p_int: 0.999963683
p_ni: 0.000036317
Score: 0.157
Data Source: BioPlex,STRINGDB
FAM162A
Tbio
Novelty: 0.03110847
p_int: 0.99963524
p_ni: 0.00036476
Score: 0.167
Data Source: BioPlex,STRINGDB
TMEM160
Tdark
Novelty: 0.73483266
p_int: 0.998861186
p_ni: 0.001138814
Data Source: BioPlex
STX4
Tbio
Novelty: 0.00831588
p_int: 0.997141552
p_ni: 0.00285842
p_wrong: 2.8e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
FBLN7
Tbio
Novelty: 0.03423924
p_int: 0.996563237
p_ni: 0.003436763
Score: 0.222
Data Source: BioPlex,STRINGDB
SMDT1
Tbio
Novelty: 0.02448475
p_int: 0.9959214
p_ni: 0.000507468
p_wrong: 0.003571132
Score: 0.175
Data Source: BioPlex,STRINGDB
NDUFAF1
Tclin
Novelty: 0.05630549
p_int: 0.995682131
p_ni: 0.004317869
Data Source: BioPlex
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.993208811
p_ni: 0.006791189
Data Source: BioPlex
Publication Statistics
PubMed Score  348.91

PubMed score by year
PubTator Score  187.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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