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Tclin
KCNMA1
Calcium-activated potassium channel subunit alpha-1

Protein Summary
Description
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phospho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286627
  • ENSP00000286627
  • ENSG00000156113
  • ENST00000286628
  • ENSP00000286628
  • ENST00000434208
  • ENSP00000402150
  • ENST00000480683
  • ENSP00000474686
  • ENST00000626620
  • ENSP00000485867
  • ENST00000638575
  • ENSP00000492049
  • ENST00000638759
  • ENSP00000492632
  • ENST00000640969
  • ENSP00000492200

Symbol
  • KCNMA
  • SLO
  • SLO
  • BKTM
  • SLO1
  • hSlo
  • MaxiK
  • PNKD3
  • SAKCA
  • mSLO1
  • CADEDS
  • KCa1.1
  • SLO-ALPHA
  • bA205K10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.96
PubMedID
0.86
biological term
0.82
disease
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1219.79   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1219.79   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
8.9
95.8
heel bone mineral density
3
3
6
95.2
Myopia
2
2
0
5
76
1
1
0
1.3
70
body mass index
1
1
1
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
8.9
95.8
heel bone mineral density
6
95.2
Myopia
0
5
76
0
1.3
70
body mass index
1
67.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium calcium-activated channel subfamily M alpha 1
574103
Mouse
MGI:99923
16531
Rat
RGD:620715
83731
Dog
potassium calcium-activated channel subfamily M alpha 1
VGNC:42281
403984
Horse
potassium calcium-activated channel subfamily M alpha 1
VGNC:19303
100064366
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium calcium-activated channel subfamily M alpha 1
Mouse
Rat
Dog
potassium calcium-activated channel subfamily M alpha 1
Horse
potassium calcium-activated channel subfamily M alpha 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12791-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Hemostasis
Reactome
Neuronal System
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Hemostasis
Neuronal System
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Gene Ontology Terms (25)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (159)
1 – 10 of 159
KCNMB1
Tbio
Family: IC
Novelty: 0.00736653
Score: 0.989
Data Source: Reactome,STRINGDB
KCNMB3
Tbio
Family: IC
Novelty: 0.08717845
Score: 0.986
Data Source: Reactome,STRINGDB
KCNMB4
Tbio
Family: IC
Novelty: 0.05362954
Score: 0.966
Data Source: Reactome,STRINGDB
KCNN4
Tchem
Family: IC
Novelty: 0.00244935
Score: 0.961
Data Source: STRINGDB
KCNN1
Tchem
Family: IC
Novelty: 0.04266994
Score: 0.955
Data Source: STRINGDB
KCNN2
Tchem
Family: IC
Novelty: 0.01865346
Score: 0.947
Data Source: STRINGDB
KCNN3
Tchem
Family: IC
Novelty: 0.00227544
Score: 0.946
Data Source: STRINGDB
PRKG2
Tchem
Family: Kinase
Novelty: 0.0138455
Score: 0.923
Data Source: Reactome,STRINGDB
KCNMB2
Tbio
Family: IC
Novelty: 0.4425394
Score: 0.916
Data Source: Reactome,STRINGDB
PRKG1
Tchem
Family: Kinase
Novelty: 0.0014943
Score: 0.892
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1219.79

PubMed score by year
PubTator Score  298.86

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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