Tbio GTF3C1 General transcription factor 3C polypeptide 1

Protein Summary

Description

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.

Uniprot Accession IDs

• Q12789
• B2RP21
• Q12838
• Q6DKN9
• Q9Y4W9

Gene Name

• GTF3C1

Ensembl ID

• ENST00000356183
• ENSP00000348510
• ENSG00000077235
• ENST00000561623
• ENSP00000455417

Symbol

• TFIIIC
• TFIIIC220
• TFIIICalpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
disease perturbation	0.83
hub protein	0.82
protein complex	0.82
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.95   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.95   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0