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Tdark
TBL3
Transducin beta-like protein 3

Protein Summary
Description
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000568546
  • ENSP00000454836
  • ENSG00000183751

Symbol
  • SAZD
  • SAZD
  • UTP13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
hub protein
0.85
histone modification site profile
0.81
kinase perturbation
0.81
cellular component
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transducin beta like 3
VGNC:9113
454343
Macaque
transducin beta like 3
693864
Mouse
MGI:2384863
213773
Rat
RGD:1305142
287120
Dog
transducin beta like 3
VGNC:47163
490064
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transducin beta like 3
Macaque
transducin beta like 3
Mouse
Rat
Dog
transducin beta like 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q12788-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (356)
1 – 10 of 356
WDR36
Tbio
Novelty: 0.02010676
p_int: 0.999415082
p_ni: 0.000584916
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.999322403
p_ni: 0.000677593
p_wrong: 4e-9
Score: 0.9
Data Source: BioPlex,STRINGDB
FAIM
Tbio
Novelty: 0.02606594
p_int: 0.999261895
p_ni: 0.000738105
Data Source: BioPlex
ARHGAP25
Tbio
Family: Enzyme
Novelty: 0.14944305
p_int: 0.831449524
p_ni: 0.168549524
p_wrong: 9.52e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
p_int: 0.816535801
p_ni: 0.183464199
Score: 0.199
Data Source: BioPlex,STRINGDB
RBM4
Tbio
Novelty: 0.02034191
p_int: 0.816535801
p_ni: 0.183464199
Data Source: BioPlex
DKKL1
Tbio
Novelty: 0.00544618
p_int: 0.791611973
p_ni: 0.208388005
p_wrong: 2.2e-8
Data Source: BioPlex
MPHOSPH10
Tbio
Novelty: 0.04846226
Score: 0.999
Data Source: STRINGDB
NOP14
Tbio
Novelty: 0.08903014
Score: 0.999
Data Source: STRINGDB
PWP2
Tbio
Novelty: 0.04910741
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.03

PubMed score by year
PubTator Score  7.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer