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Tbio
FOXO1
Forkhead box protein O1

Protein Summary
Description
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and ST ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379561
  • ENSP00000368880
  • ENSG00000150907

Symbol
  • FKHR
  • FOXO1A
  • FKH1
  • FKHR
  • FOXO1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
kinase
1
hub protein
0.99
virus perturbation
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1988.35   (req: < 5)
Gene RIFs: 478   (req: <= 3)
Antibodies: 1900   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1988.35   (req: >= 5)
Gene RIFs: 478   (req: > 3)
Antibodies: 1900   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
94.7
mean corpuscular volume
3
3
3
90
corneal hysteresis
2
2
2
89.8
mean corpuscular hemoglobin concentration
2
2
2
89.8
eosinophil percentage of leukocytes
2
2
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
94.7
mean corpuscular volume
3
90
corneal hysteresis
2
89.8
mean corpuscular hemoglobin concentration
2
89.8
eosinophil percentage of leukocytes
2
83.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box O1
VGNC:14510
467352
Macaque
forkhead box O1
700030
Mouse
MGI:1890077
56458
Rat
RGD:620283
84482
Dog
forkhead box O1
VGNC:49897
477295
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box O1
Macaque
forkhead box O1
Mouse
Rat
Dog
forkhead box O1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12778-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (98)
AKT phosphorylates targets in the nucleus (R-HSA-198693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the nucleus
Reactome
AKT-mediated inactivation of FOXO1A
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
Constitutive Signaling by AKT1 E17K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Gene Ontology Terms (55)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (405)
1 – 10 of 405
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.998
Data Source:  Reactome,STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.995
Data Source:  Reactome,STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.981
Data Source:  Reactome,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.98
Data Source:  STRINGDB
CEBPB
Tbio
Family:  TF
Novelty:  0.00068108
Score:  0.98
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.98
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.979
Data Source:  Reactome,STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.978
Data Source:  Reactome,STRINGDB
CDKN1B
Tbio
Family:  Enzyme
Novelty:  0.00069449
Score:  0.974
Data Source:  STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.973
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1988.35

PubMed score by year
PubTator Score  959.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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