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Tchem
SREBF2
Sterol regulatory element-binding protein 2

Protein Summary
Description
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361204
  • ENSP00000354476
  • ENSG00000198911

Symbol
  • BHLHD2
  • SREBP2
  • SREBP2
  • bHLHd2
  • SREBP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor binding site profile
0.93
disease perturbation
0.9
hub protein
0.85
cellular component
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.16   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.16   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
3
0
5.6
83.7
mathematical ability
1
1
1
68.5
smoking status measurement
1
1
1
67.9
birth weight
1
1
1
56.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
5.6
83.7
mathematical ability
1
68.5
smoking status measurement
1
67.9
birth weight
1
56.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107585
20788
Rat
RGD:1307751
300095
Dog
sterol regulatory element binding transcription factor 2
VGNC:46796
481228
Horse
sterol regulatory element binding transcription factor 2
VGNC:23577
100070704
Cow
sterol regulatory element binding transcription factor 2
VGNC:35275
507102
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
sterol regulatory element binding transcription factor 2
Horse
sterol regulatory element binding transcription factor 2
Cow
sterol regulatory element binding transcription factor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12772-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Developmental Biology
Metabolism
Metabolism of lipids
Metabolism of steroids
Gene Ontology Terms (32)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (192)
1 – 10 of 192
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.96016819
p_ni: 0.03983181
Score: 0.264
Data Source: BioPlex,STRINGDB
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.957653186
p_ni: 0.042346814
Data Source: BioPlex
HLA-DPA1
Tbio
Novelty: 0.01080446
p_int: 0.937945272
p_ni: 0.062054728
Data Source: BioPlex
TMCO3
Tdark
Novelty: 1.16719823
p_int: 0.909330368
p_ni: 0.090669632
Data Source: BioPlex
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.905200188
p_ni: 0.094799812
Data Source: BioPlex
CHRND
Tclin
Family: IC
Novelty: 0.0441685
p_int: 0.883256748
p_ni: 0.116743252
Data Source: BioPlex
IL17RC
Tclin
Novelty: 0.01844832
p_int: 0.86511771
p_ni: 0.13488229
Data Source: BioPlex
NRG1
Tbio
Novelty: 0.00095246
p_int: 0.861697748
p_ni: 0.138302252
Score: 0.254
Data Source: BioPlex,STRINGDB
CD79B
Tclin
Novelty: 0.00227414
p_int: 0.860873097
p_ni: 0.139126884
p_wrong: 1.9e-8
Data Source: BioPlex
SLC4A8
Tbio
Family: Transporter
Novelty: 0.01606111
p_int: 0.854317659
p_ni: 0.145682341
Data Source: BioPlex
Publication Statistics
PubMed Score  551.16

PubMed score by year
PubTator Score  301.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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