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Tbio
SCAP
Sterol regulatory element-binding protein cleavage-activating protein

Protein Summary
Description
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265565
  • ENSP00000265565
  • ENSG00000114650
  • ENST00000648151
  • ENSP00000497087

Symbol
  • KIAA0199
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.88
transcription factor binding site profile
0.86
histone modification site profile
0.85
protein domain
0.85
interacting protein
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.93   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.93   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.987299885
p_ni:  0.012700115
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.980787359
p_ni:  0.019212641
Data Source:  BioPlex
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.845118728
p_ni:  0.154881272
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.830551455
p_ni:  0.169448545
Data Source:  BioPlex
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.808058006
p_ni:  0.191941994
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.797249338
p_ni:  0.202750662
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.761875221
p_ni:  0.238124779
Score:  0.232
Data Source:  BioPlex,STRINGDB
SREBF2
Tchem
Family:  TF
Novelty:  0.00171709
Score:  0.998
Data Source:  Reactome,STRINGDB
INSIG1
Tbio
Novelty:  0.00999942
Score:  0.993
Data Source:  Reactome,STRINGDB
INSIG2
Tbio
Novelty:  0.00980894
Score:  0.982
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (46)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Metabolism of steroids
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
2
2
82
sex hormone-binding globulin measurement
2
1
2
78.1
smoking status measurement
1
1
1
59.6
heel bone mineral density
1
1
1
29
triglyceride measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
2
82
sex hormone-binding globulin measurement
2
78.1
smoking status measurement
1
59.6
heel bone mineral density
1
29
triglyceride measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SREBF chaperone
VGNC:12181
460334
Macaque
SREBF chaperone
711528
Mouse
MGI:2135958
235623
Rat
RGD:1309378
301024
Dog
SREBF chaperone
VGNC:45894
484782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SREBF chaperone
Macaque
SREBF chaperone
Mouse
Rat
Dog
SREBF chaperone
Publication Statistics
PubMed Score 111.93
PubMed score by year
PubTator Score 189.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title