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Tbio
NUP160
Nuclear pore complex protein Nup160

Protein Classes
Protein Summary
Description
Involved in poly(A)+ RNA transport. NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378460
  • ENSP00000367721
  • ENSG00000030066
  • ENST00000526870
  • ENSP00000431495
  • ENST00000643285
  • ENSP00000495820
  • ENSG00000285358
  • ENST00000645800
  • ENSP00000496541

Symbol
  • KIAA0197
  • NUP120
  • NPHS19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
1
virus perturbation
0.88
kinase perturbation
0.84
transcription factor binding site profile
0.84
histone modification site profile
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.29   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.29   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
90.9
neuroticism measurement
4
3
2
6.2
87.3
self reported educational attainment
2
2
2
85
wellbeing measurement
2
1
2
78.8
heel bone mineral density
1
1
1
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
90.9
neuroticism measurement
2
6.2
87.3
self reported educational attainment
2
85
wellbeing measurement
2
78.8
heel bone mineral density
1
77.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 160
VGNC:1080
451179
Macaque
nucleoporin 160
710968
Mouse
MGI:1926227
59015
Rat
RGD:1311052
311182
Dog
nucleoporin 160
VGNC:44047
483618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 160
Macaque
nucleoporin 160
Mouse
Rat
Dog
nucleoporin 160
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12769-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (82)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 81
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (261)
1 – 10 of 261
NUP133
Tbio
Novelty: 0.02115225
p_int: 0.999650262
p_ni: 0.000349738
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP43
Tbio
Novelty: 0.11571309
p_int: 0.998616281
p_ni: 0.001383359
p_wrong: 3.6e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
SEC13
Tbio
Novelty: 0.00709413
p_int: 0.984924171
p_ni: 0.015075829
Score: 0.998
Data Source: BioPlex,STRINGDB
UXS1
Tbio
Family: Enzyme
Novelty: 0.04671281
p_int: 0.969997974
p_ni: 0.030002026
Data Source: BioPlex
VASN
Tbio
Novelty: 0.05424159
p_int: 0.936008824
p_ni: 0.063991176
Data Source: BioPlex
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.910692463
p_ni: 0.089307534
p_wrong: 2e-9
Data Source: BioPlex
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.839171966
p_ni: 0.160828033
p_wrong: 1e-9
Data Source: BioPlex
SIGLECL1
Tdark
p_int: 0.833610026
p_ni: 0.166389973
p_wrong: 1e-9
Data Source: BioPlex
CADPS
Tbio
Novelty: 0.01737775
p_int: 0.814755505
p_ni: 0.185244495
Data Source: BioPlex
CD70
Tbio
Novelty: 0.00420393
p_int: 0.791209268
p_ni: 0.208790731
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  26.29

PubMed score by year
PubTator Score  4.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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