You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KIF1A
Kinesin-like protein KIF1A

Protein Summary
Description
Motor for anterograde axonal transport of synaptic vesicle precursors. The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404283
  • ENSP00000384231
  • ENSG00000130294
  • ENST00000498729
  • ENSP00000438388
  • ENST00000649096
  • ENSP00000497030
  • ENST00000650053
  • ENSP00000497824

Symbol
  • ATSV
  • C2orf20
  • ATSV
  • MRD9
  • HSN2C
  • SPG30
  • UNC104
  • C2orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
disease perturbation
0.79
interacting protein
0.73
PubMedID
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.81   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.81   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
45.6
body height
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
45.6
body height
1
1.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 1A
VGNC:14147
460072
Macaque
kinesin family member 1A
716855
Mouse
MGI:108391
16560
Rat
RGD:1304996
363288
Dog
kinesin family member 1A
VGNC:42390
486202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 1A
Macaque
kinesin family member 1A
Mouse
Rat
Dog
kinesin family member 1A
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12756-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (26)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (235)
1 – 10 of 235
KIF1B
Tbio
Novelty: 0.00984332
p_int: 0.99999988
p_ni: 1.19e-7
Score: 0.971
Data Source: BioPlex,STRINGDB
CETN1
Tbio
Novelty: 0.01208917
p_int: 0.999999705
p_ni: 2.95e-7
Score: 0.18
Data Source: BioPlex,STRINGDB
KIF1BP
Tbio
Novelty: 0.03932922
p_int: 0.999999294
p_ni: 7.06e-7
Score: 0.677
Data Source: BioPlex,STRINGDB
TEPSIN
Tdark
Novelty: 0.48775142
p_int: 0.999777797
p_ni: 0.000222203
Data Source: BioPlex
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.999343176
p_ni: 0.000656796
p_wrong: 2.8e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.995617581
p_ni: 0.004382418
Data Source: BioPlex
IMP3
Tbio
Novelty: 0.42681287
p_int: 0.991571306
p_ni: 0.008428694
Data Source: BioPlex
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.973930627
p_ni: 0.026069351
p_wrong: 2.2e-8
Data Source: BioPlex
DQX1
Tdark
Family: Enzyme
Novelty: 1.01984582
p_int: 0.948897139
p_ni: 0.051091485
p_wrong: 0.000011376
Score: 0.248
Data Source: BioPlex,STRINGDB
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.933201069
p_ni: 0.060691868
p_wrong: 0.006107063
Data Source: BioPlex
Publication Statistics
PubMed Score  216.81

PubMed score by year
PubTator Score  101.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: