KIF1A
Kinesin-like protein KIF1A
Protein Summary
Motor for anterograde axonal transport of synaptic vesicle precursors. The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
- ENST00000404283
- ENSP00000384231
- ENSG00000130294
- ENST00000498729
- ENSP00000438388
- ENST00000649096
- ENSP00000497030
- ENST00000650053
- ENSP00000497824
- ATSV
- C2orf20
- ATSV
- MRD9
- HSN2C
- SPG30
- UNC104
- C2orf20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.98 | ||
disease perturbation | 0.79 | ||
interacting protein | 0.73 | ||
PubMedID | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.59 (req: < 5)
Gene RIFs: 48 (req: <= 3)
Antibodies: 46 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.59 (req: >= 5)
Gene RIFs: 48 (req: > 3)
Antibodies: 46 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0