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Tbio
ST3GAL3
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

Protein Summary
Description
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with a form of autosomal recessive nonsymdromic cognitive disability as well as infantile epileptic encephalopathy. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262915
  • ENSP00000262915
  • ENSG00000126091
  • ENST00000330208
  • ENSP00000333494
  • ENST00000335430
  • ENSP00000335633
  • ENST00000347631
  • ENSP00000317192
  • ENST00000351035
  • ENSP00000316999
  • ENST00000353126
  • ENSP00000330463
  • ENST00000361392
  • ENSP00000355341
  • ENST00000361400
  • ENSP00000354748
  • ENST00000361812
  • ENSP00000355201
  • ENST00000372362
  • ENSP00000361437
  • ENST00000372365
  • ENSP00000361440
  • ENST00000372366
  • ENSP00000361441
  • ENST00000372367
  • ENSP00000361442
  • ENST00000372369
  • ENSP00000361444
  • ENST00000372372
  • ENSP00000361447
  • ENST00000372374
  • ENSP00000361449
  • ENST00000469715
  • ENSP00000431700
  • ENST00000489897
  • ENSP00000437206
  • ENST00000490541
  • ENSP00000435018
  • ENST00000528371
  • ENSP00000434876
  • ENST00000530581
  • ENSP00000437293
  • ENST00000531451
  • ENSP00000435603
  • ENST00000531816
  • ENSP00000434378
  • ENST00000531993
  • ENSP00000432682
  • ENST00000533212
  • ENSP00000435621
  • ENST00000533997
  • ENSP00000432071
  • ENST00000545417
  • ENSP00000439634
  • ENST00000642504
  • ENSP00000494857
  • ENST00000642934
  • ENSP00000494146
  • ENST00000642949
  • ENSP00000495709
  • ENST00000644195
  • ENSP00000494201
  • ENST00000645142
  • ENSP00000496550
  • ENST00000645165
  • ENSP00000493660
  • ENST00000645640
  • ENSP00000494852
  • ENST00000646971
  • ENSP00000495887

Symbol
  • SIAT6
  • ST3N
  • MRT12
  • SIAT6
  • EIEE15
  • ST3GALII
  • ST3GalIII
  • ST3Gal III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
histone modification site profile
0.9
transcription factor
0.83
transcription factor binding site profile
0.69
pathway
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.16   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.16   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0