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Tbio
ST3GAL3
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

Protein Summary
Description
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with a form of autosomal recessive nonsymdromic cognitive disability as well as infantile epileptic encephalopathy. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262915
  • ENSP00000262915
  • ENSG00000126091
  • ENST00000330208
  • ENSP00000333494
  • ENST00000335430
  • ENSP00000335633
  • ENST00000347631
  • ENSP00000317192
  • ENST00000351035
  • ENSP00000316999
  • ENST00000353126
  • ENSP00000330463
  • ENST00000361392
  • ENSP00000355341
  • ENST00000361400
  • ENSP00000354748
  • ENST00000361812
  • ENSP00000355201
  • ENST00000372362
  • ENSP00000361437
  • ENST00000372365
  • ENSP00000361440
  • ENST00000372366
  • ENSP00000361441
  • ENST00000372367
  • ENSP00000361442
  • ENST00000372369
  • ENSP00000361444
  • ENST00000372372
  • ENSP00000361447
  • ENST00000372374
  • ENSP00000361449
  • ENST00000469715
  • ENSP00000431700
  • ENST00000489897
  • ENSP00000437206
  • ENST00000490541
  • ENSP00000435018
  • ENST00000528371
  • ENSP00000434876
  • ENST00000530581
  • ENSP00000437293
  • ENST00000531451
  • ENSP00000435603
  • ENST00000531816
  • ENSP00000434378
  • ENST00000531993
  • ENSP00000432682
  • ENST00000533212
  • ENSP00000435621
  • ENST00000533997
  • ENSP00000432071
  • ENST00000545417
  • ENSP00000439634
  • ENST00000642504
  • ENSP00000494857
  • ENST00000642934
  • ENSP00000494146
  • ENST00000642949
  • ENSP00000495709
  • ENST00000644195
  • ENSP00000494201
  • ENST00000645142
  • ENSP00000496550
  • ENST00000645165
  • ENSP00000493660
  • ENST00000645640
  • ENSP00000494852
  • ENST00000646971
  • ENSP00000495887

Symbol
  • SIAT6
  • ST3N
  • MRT12
  • SIAT6
  • EIEE15
  • ST3GALII
  • ST3GalIII
  • ST3Gal III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
histone modification site profile
0.9
transcription factor
0.83
transcription factor binding site profile
0.69
pathway
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.77   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.77   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
SERPINB9
Tbio
Novelty:  0.00473022
p_int:  0.999999731
p_ni:  1.95e-7
p_wrong:  7.4e-8
Data Source:  BioPlex
RABEPK
Tdark
Novelty:  0.97019495
p_int:  0.999998712
p_ni:  4.54e-7
p_wrong:  8.34e-7
Data Source:  BioPlex
SPCS1
Tbio
Family:  Enzyme
Novelty:  0.0731223
p_int:  0.974004509
p_ni:  0.004683099
p_wrong:  0.021312392
Data Source:  BioPlex
GALNT12
Tbio
Family:  Enzyme
Novelty:  0.085131
p_int:  0.887932645
p_ni:  0.11206324
p_wrong:  0.000004115
Score:  0.449
Data Source:  BioPlex,STRINGDB
C6orf120
Tdark
Novelty:  0.90888293
p_int:  0.819778959
p_ni:  0.180217213
p_wrong:  0.000003828
Data Source:  BioPlex
B4GALT2
Tbio
Family:  Enzyme
Novelty:  0.03492512
Score:  0.966
Data Source:  STRINGDB
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.965
Data Source:  STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.942
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.933
Data Source:  STRINGDB
B4GALT3
Tbio
Family:  Enzyme
Novelty:  0.04015046
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Blood group systems biosynthesis
Reactome
Defective ST3GAL3 causes MCT12 and EIEE15
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Blood group systems biosynthesis
Defective ST3GAL3 causes MCT12 and EIEE15
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
9
9
6
96.2
mathematical ability
4
3
5
93.5
alkaline phosphatase measurement
2
2
1
7.3
89
smoking initiation
2
2
2
86.3
7
4
2
1.1
81.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
9
6
96.2
mathematical ability
5
93.5
alkaline phosphatase measurement
1
7.3
89
smoking initiation
2
86.3
2
1.1
81.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
VGNC:10429
456832
Macaque
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
703599
Mouse
MGI:1316659
20441
Rat
RGD:68414
64445
Horse
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
VGNC:23629
100053104
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Macaque
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Mouse
Rat
Horse
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Publication Statistics
PubMed Score 63.77
PubMed score by year
PubTator Score 39.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title