Tchem ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Protein Summary

Description

Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q11201
• O60677
• Q9UN51
• Alpha 2,3-ST 1

Gene Name

• ST3GAL1

Ensembl ID

• ENST00000399640
• ENSP00000414073
• ENSG00000008513
• ENST00000521180
• ENSP00000428540
• ENST00000522652
• ENSP00000430515
• ENST00000648219
• ENSP00000497381

Symbol

• SIAT4
• SIAT4A
• ST3O
• SIAT4A
• SIATFL
• ST3GalA
• ST3GalIA
• Gal-NAc6S
• ST3GalA.1
• ST3GalIA,1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
transcription factor perturbation	0.91
transcription factor binding site profile	0.89
gene perturbation	0.88
PubMedID	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.89   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.89   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0