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Tbio
TEF
Thyrotroph embryonic factor

Protein Summary
Description
Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and sh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266304
  • ENSP00000266304
  • ENSG00000167074
  • ENST00000406644
  • ENSP00000385256

Symbol
  • KIAA1655
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.89
transcription factor binding site profile
0.74
disease
0.66
small molecule perturbation
0.63
tissue
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.37   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.37   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
6.6
81
1
1
0
1.3
68
smoking behaviour measurement
1
1
1
18.7
alcohol consumption measurement
2
1
2
17.5
lymphocyte percentage of leukocytes
1
1
1
16.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
6.6
81
0
1.3
68
smoking behaviour measurement
1
18.7
alcohol consumption measurement
2
17.5
lymphocyte percentage of leukocytes
1
16.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TEF, PAR bZIP transcription factor
VGNC:7344
470222
Macaque
TEF, PAR bZIP transcription factor
707009
Mouse
MGI:98663
21685
Rat
RGD:3841
29362
Dog
TEF, PAR bZIP transcription factor
VGNC:47239
607883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TEF, PAR bZIP transcription factor
Macaque
TEF, PAR bZIP transcription factor
Mouse
Rat
Dog
TEF, PAR bZIP transcription factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q10587-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (63)
1 – 10 of 63
NR1D1
Tchem
Family: NR
Novelty: 0.00250799
Score: 0.763
Data Source: STRINGDB
PDXK
Tbio
Family: Kinase
Novelty: 0.00976418
Score: 0.753
Data Source: STRINGDB
PER3
Tbio
Novelty: 0.00350199
Score: 0.733
Data Source: STRINGDB
TTF2
Tbio
Novelty: 0.20281859
Score: 0.719
Data Source: STRINGDB
DBP
Tbio
Family: TF
Novelty: 0.02264853
Score: 0.718
Data Source: STRINGDB
EYA3
Tbio
Novelty: 0.05588286
Score: 0.715
Data Source: STRINGDB
TEAD1
Tbio
Family: TF
Novelty: 0.01198524
Score: 0.712
Data Source: STRINGDB
CRY1
Tchem
Novelty: 0.00116593
Score: 0.712
Data Source: STRINGDB
CRY2
Tbio
Novelty: 0.00156961
Score: 0.7
Data Source: STRINGDB
ARNTL
Tbio
Family: TF
Novelty: 0.00102829
Score: 0.695
Data Source: STRINGDB
Publication Statistics
PubMed Score  111.37

PubMed score by year
PubTator Score  21.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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