Tbio TEF Thyrotroph embryonic factor

Protein Summary

Description

Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q10587
• B0QYS8
• B2RC22
• Q15729
• Q7Z3J7
• Q8IU94
• Q96TG4

Gene Name

• TEF

Ensembl ID

• ENST00000266304
• ENSP00000266304
• ENSG00000167074
• ENST00000406644
• ENSP00000385256

Symbol

• KIAA1655

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.89
transcription factor binding site profile	0.74
disease	0.66
small molecule perturbation	0.63
tissue	0.63

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Thyrotroph Embryonic Factor

Protein / Nucleic Acid Binding / Thyrotroph Embryonic Factor

DTO Classes

Protein / Nucleic Acid Binding / Thyrotroph Embryonic Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.52   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.52   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0