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Tbio
CPSF1
Cleavage and polyadenylation specificity factor subunit 1

Protein Classes
Protein Summary
Description
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000616140
  • ENSP00000484669
  • ENSG00000071894
  • ENST00000620219
  • ENSP00000478145
  • ENST00000643746
  • ENSP00000495102
  • ENSG00000285049
  • ENST00000644539
  • ENSP00000495020

Symbol
  • CPSF160
  • CPSF160
  • P/cl.18
  • HSU37012
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
transcription factor binding site profile
0.87
tissue sample
0.66
histone modification site profile
0.59
tissue
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cleavage and polyadenylation specific factor 1
702082
Mouse
MGI:2679722
94230
Rat
RGD:1306406
366952
Dog
cleavage and polyadenylation specific factor 1
VGNC:39573
475126
Horse
cleavage and polyadenylation specific factor 1
VGNC:16833
100063277
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cleavage and polyadenylation specific factor 1
Mouse
Rat
Dog
cleavage and polyadenylation specific factor 1
Horse
cleavage and polyadenylation specific factor 1
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (306)
1 – 10 of 306
CPSF4
Tbio
Novelty: 0.00206207
p_int: 0.966291375
p_ni: 0.033708625
Score: 0.999
Data Source: BioPlex,STRINGDB
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.83234089
p_ni: 0.16765911
Data Source: BioPlex
WDR33
Tbio
Novelty: 0.09221439
Score: 0.999
Data Source: STRINGDB
CPSF3
Tchem
Novelty: 0.01880576
Score: 0.999
Data Source: STRINGDB
FIP1L1
Tbio
Novelty: 0.00520044
Score: 0.999
Data Source: STRINGDB
SYMPK
Tbio
Novelty: 0.01773552
Score: 0.999
Data Source: STRINGDB
CSTF3
Tbio
Novelty: 0.05260909
Score: 0.999
Data Source: STRINGDB
CPSF2
Tbio
Novelty: 0.0510853
Score: 0.999
Data Source: STRINGDB
CSTF2
Tbio
Novelty: 0.01389909
Score: 0.997
Data Source: STRINGDB
PAPOLA
Tbio
Family: Enzyme
Novelty: 0.11047902
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.00

PubMed score by year
PubTator Score  8.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer