CPSF1
Cleavage and polyadenylation specificity factor subunit 1
Protein Summary
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
- ENST00000616140
- ENSP00000484669
- ENSG00000071894
- ENST00000620219
- ENSP00000478145
- ENST00000643746
- ENSP00000495102
- ENSG00000285049
- ENST00000644539
- ENSP00000495020
- CPSF160
- CPSF160
- P/cl.18
- HSU37012
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.88 | ||
transcription factor binding site profile | 0.87 | ||
tissue sample | 0.66 | ||
histone modification site profile | 0.59 | ||
tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (306)
CPSF4
Novelty: 0.00206207
p_int: 0.966291375
p_ni: 0.033708625
Score: 0.999
Data Source: BioPlex,STRINGDB
P4HA1
Family: Enzyme
Novelty: 0.01624726
p_int: 0.83234089
p_ni: 0.16765911
Data Source: BioPlex
Nearest Tclin Targets
Pathways (17)
Reactome (15)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | Processing of Capped Intronless Pre-mRNA | ||||
Reactome | Processing of Intronless Pre-mRNAs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
Processing of Capped Intronless Pre-mRNA | ||||
Processing of Intronless Pre-mRNAs | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 2 | 2 | 1 | 8 | 94.2 | ||||
mathematical ability | 4 | 4 | 4 | 93.4 | |||||
sex hormone-binding globulin measurement | 6 | 2 | 6 | 90.7 | |||||
self reported educational attainment | 3 | 2 | 3 | 83.3 | |||||
2 | 2 | 2 | 79.4 | ||||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 8 | 94.2 | ||||
mathematical ability | 4 | 93.4 | |||||
sex hormone-binding globulin measurement | 6 | 90.7 | |||||
self reported educational attainment | 3 | 83.3 | |||||
2 | 79.4 | ||||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cleavage and polyadenylation specific factor 1 | 702082 | ||||||
Mouse | MGI:2679722 | 94230 | ||||||
Rat | RGD:1306406 | 366952 | ||||||
Dog | cleavage and polyadenylation specific factor 1 | VGNC:39573 | 475126 | |||||
Horse | cleavage and polyadenylation specific factor 1 | VGNC:16833 | 100063277 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cleavage and polyadenylation specific factor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cleavage and polyadenylation specific factor 1 | |||||
Horse | cleavage and polyadenylation specific factor 1 | |||||
Publication Statistics
PubMed Score 21.00
PubMed score by year
PubTator Score 8.72
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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