CPSF1
Cleavage and polyadenylation specificity factor subunit 1
Protein Classes
Protein Summary
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
- ENST00000616140
- ENSP00000484669
- ENSG00000071894
- ENST00000620219
- ENSP00000478145
- ENST00000643746
- ENSP00000495102
- ENSG00000285049
- ENST00000644539
- ENSP00000495020
- CPSF160
- CPSF160
- P/cl.18
- HSU37012
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.88 | ||
transcription factor binding site profile | 0.87 | ||
tissue sample | 0.66 | ||
histone modification site profile | 0.59 | ||
tissue | 0.57 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cleavage and polyadenylation specific factor 1 | 702082 | ||||||
Mouse | MGI:2679722 | 94230 | ||||||
Rat | RGD:1306406 | 366952 | ||||||
Dog | cleavage and polyadenylation specific factor 1 | VGNC:39573 | 475126 | |||||
Horse | cleavage and polyadenylation specific factor 1 | VGNC:16833 | 100063277 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cleavage and polyadenylation specific factor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cleavage and polyadenylation specific factor 1 | |||||
Horse | cleavage and polyadenylation specific factor 1 | |||||
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (17)
Reactome (15)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | Processing of Capped Intronless Pre-mRNA | ||||
Reactome | Processing of Intronless Pre-mRNAs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
Processing of Capped Intronless Pre-mRNA | ||||
Processing of Intronless Pre-mRNAs | ||||
Gene Ontology Terms (11)
Functions (2)
Components (3)
Processes (6)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Protein-Protein Interactions (306)
1 – 10 of 306
CPSF4
Novelty: 0.00206207
p_int: 0.966291375
p_ni: 0.033708625
Score: 0.999
Data Source: BioPlex,STRINGDB
P4HA1
Family: Enzyme
Novelty: 0.01624726
p_int: 0.83234089
p_ni: 0.16765911
Data Source: BioPlex
WDR33
Novelty: 0.09221439
Score: 0.999
Data Source: STRINGDB
CPSF3
Novelty: 0.01880576
Score: 0.999
Data Source: STRINGDB
FIP1L1
Novelty: 0.00520044
Score: 0.999
Data Source: STRINGDB
SYMPK
Novelty: 0.01773552
Score: 0.999
Data Source: STRINGDB
CSTF3
Novelty: 0.05260909
Score: 0.999
Data Source: STRINGDB
CPSF2
Novelty: 0.0510853
Score: 0.999
Data Source: STRINGDB
CSTF2
Novelty: 0.01389909
Score: 0.997
Data Source: STRINGDB
PAPOLA
Family: Enzyme
Novelty: 0.11047902
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score 21.00
PubMed score by year
PubTator Score 8.72
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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