Tbio CPSF1 Cleavage and polyadenylation specificity factor subunit 1

Protein Summary

Description

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q10570
• Q96AF0

Gene Name

• CPSF1

Ensembl ID

• ENST00000616140
• ENSP00000484669
• ENSG00000071894
• ENST00000620219
• ENSP00000478145
• ENST00000643746
• ENSP00000495102
• ENSG00000285049
• ENST00000644539
• ENSP00000495020

Symbol

• CPSF160
• CPSF160
• P/cl.18
• HSU37012

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.88
transcription factor binding site profile	0.87
tissue sample	0.66
histone modification site profile	0.59
tissue	0.57

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Cleavage And Polyadenylation Specificity Factor Subunit 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Damaged Dna-binding Protein / Cleavage And Polyadenylation Specificity Factor Subunit 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Cleavage And Polyadenylation Specificity Factor Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.15   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.15   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0