Tbio AP1B1 AP-1 complex subunit beta-1

Protein Summary

Description

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q10567
• C9JRD1
• F8WDL0
• P78436
• Q20WL3
• Q86X54

Gene Name

• AP1B1

Ensembl ID

• ENST00000317368
• ENSP00000319361
• ENSG00000100280
• ENST00000357586
• ENSP00000350199
• ENST00000402502
• ENSP00000386071
• ENST00000405198
• ENSP00000384194
• ENST00000415447
• ENSP00000387612
• ENST00000432560
• ENSP00000400065

Symbol

• ADTB1
• BAM22
• CLAPB2
• ADTB1
• BAM22
• AP105A
• CLAPB2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein domain	1
disease perturbation	0.93
hub protein	0.82
cellular component	0.75

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Ap-1 Complex Subunit Beta-1

DTO Classes

Protein / Transporter / Ap-1 Complex Subunit Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.4   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.4   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0