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Tbio
AP1B1
AP-1 complex subunit beta-1

Protein Summary
Description
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317368
  • ENSP00000319361
  • ENSG00000100280
  • ENST00000357586
  • ENSP00000350199
  • ENST00000402502
  • ENSP00000386071
  • ENST00000405198
  • ENSP00000384194
  • ENST00000415447
  • ENSP00000387612
  • ENST00000432560
  • ENSP00000400065

Symbol
  • ADTB1
  • BAM22
  • CLAPB2
  • ADTB1
  • BAM22
  • AP105A
  • CLAPB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
disease perturbation
0.93
hub protein
0.82
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.65   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.65   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
95.6
reticulocyte count
5
3
5
73.2
reticulocyte measurement
3
2
3
65.2
1
1
1
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
95.6
reticulocyte count
5
73.2
reticulocyte measurement
3
65.2
1
46
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Disease
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Disease
Golgi Associated Vesicle Biogenesis
HIV Infection
Host Interactions of HIV factors
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (214)
1 – 10 of 214
AP1S2
Tbio
Novelty: 0.01413503
p_int: 0.999998972
p_ni: 0.000001028
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999998212
p_ni: 0.000001788
Score: 0.993
Data Source: BioPlex,STRINGDB
EPS15L1
Tbio
Novelty: 0.06929299
p_int: 0.999996027
p_ni: 0.000003973
Score: 0.655
Data Source: BioPlex,STRINGDB
MEA1
Tbio
Novelty: 0.04292367
p_int: 0.999995191
p_ni: 0.000004809
Data Source: BioPlex
AP1S3
Tbio
Novelty: 0.14425094
p_int: 0.999994747
p_ni: 0.000005253
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
AP1M2
Tbio
Novelty: 0.02984354
p_int: 0.999993878
p_ni: 0.000006122
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
NECAP2
Tdark
Novelty: 0.4141034
p_int: 0.999993696
p_ni: 0.000006304
Score: 0.753
Data Source: BioPlex,STRINGDB
AP2S1
Tbio
Novelty: 0.01931502
p_int: 0.999973336
p_ni: 0.000026661
p_wrong: 3e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
AMPH
Tbio
Novelty: 0.00201043
p_int: 0.999742773
p_ni: 0.000257227
Score: 0.641
Data Source: BioPlex,STRINGDB
ARFGAP1
Tbio
Family: Enzyme
Novelty: 0.02654081
p_int: 0.999158248
p_ni: 0.000841752
Score: 0.349
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.65

PubMed score by year
PubTator Score  8.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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