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Tbio
GALNT1
Polypeptide N-acetylgalactosaminyltransferase 1

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the litera ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269195
  • ENSP00000269195
  • ENSG00000141429
  • ENST00000591081
  • ENSP00000466411
  • ENST00000591924
  • ENSP00000465699

Symbol
  • GALNAC-T1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.97
kinase perturbation
0.88
virus perturbation
0.76
PubMedID
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 1
VGNC:14784
468521
Macaque
polypeptide N-acetylgalactosaminyltransferase 1
708930
Mouse
MGI:894693
14423
Rat
RGD:620358
79214
Dog
polypeptide N-acetylgalactosaminyltransferase 1
VGNC:41084
480161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 1
Macaque
polypeptide N-acetylgalactosaminyltransferase 1
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q10472-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Metabolism of proteins
Protein-Protein Interactions (78)
1 – 10 of 78
GALNT13
Tbio
Family: Enzyme
Novelty: 0.12592259
p_int: 0.998179595
p_ni: 0.001820405
Score: 0.689
Data Source: BioPlex,STRINGDB
P2RX4
Tchem
Family: IC
Novelty: 0.00242958
p_int: 0.824494587
p_ni: 0.175505413
Score: 0.195
Data Source: BioPlex,STRINGDB
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01191596
Score: 0.965
Data Source: STRINGDB
MUC1
Tbio
Novelty: 0.00024203
Score: 0.962
Data Source: STRINGDB
MUC3A
Tbio
Novelty: 0.0576775
Score: 0.952
Data Source: STRINGDB
MUC5AC
Tbio
Novelty: 0.00074159
Score: 0.935
Data Source: STRINGDB
MUC7
Tbio
Novelty: 0.00750654
Score: 0.932
Data Source: STRINGDB
MUC6
Tbio
Novelty: 0.00304872
Score: 0.926
Data Source: STRINGDB
MUC4
Tbio
Novelty: 0.00193208
Score: 0.92
Data Source: STRINGDB
MUC5B
Tbio
Novelty: 0.000832
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.55

PubMed score by year
PubTator Score  31.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer