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Tbio
GALNT2
Polypeptide N-acetylgalactosaminyltransferase 2

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366672
  • ENSP00000355632
  • ENSG00000143641

Symbol
  • GalNAc-T2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
kinase perturbation
0.84
transcription factor perturbation
0.84
disease perturbation
0.83
virus perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.13   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.13   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
15
11
28
99.2
triglyceride measurement
14
11
24
2.8
98.5
red blood cell distribution width
4
5
5
93.4
metabolic syndrome
2
2
2
92.9
vitamin D measurement
3
3
3
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
28
99.2
triglyceride measurement
24
2.8
98.5
red blood cell distribution width
5
93.4
metabolic syndrome
2
92.9
vitamin D measurement
3
89.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 2
VGNC:11437
457808
Macaque
polypeptide N-acetylgalactosaminyltransferase 2
714371
Mouse
MGI:894694
108148
Rat
RGD:1310692
292090
Dog
polypeptide N-acetylgalactosaminyltransferase 2
VGNC:41094
100682763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 2
Macaque
polypeptide N-acetylgalactosaminyltransferase 2
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 2
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Metabolism of proteins
Protein-Protein Interactions (133)
1 – 10 of 133
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.9962108
p_ni: 0.0037892
Score: 0.195
Data Source: BioPlex,STRINGDB
LRTM2
Tdark
Novelty: 1.14285986
p_int: 0.994537036
p_ni: 0.005462964
Data Source: BioPlex
TGOLN2
Tbio
Novelty: 0.005107
p_int: 0.926019565
p_ni: 0.073980435
Score: 0.371
Data Source: BioPlex,STRINGDB
PIANP
Tbio
Novelty: 0.01739512
p_int: 0.840210945
p_ni: 0.159789055
Score: 0.193
Data Source: BioPlex,STRINGDB
MUC1
Tbio
Novelty: 0.00024203
Score: 0.96
Data Source: STRINGDB
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01191596
Score: 0.957
Data Source: STRINGDB
MUC7
Tbio
Novelty: 0.00750654
Score: 0.944
Data Source: STRINGDB
MUC5AC
Tbio
Novelty: 0.00074159
Score: 0.936
Data Source: STRINGDB
MUC13
Tbio
Novelty: 0.01282861
Score: 0.925
Data Source: STRINGDB
MUC6
Tbio
Novelty: 0.00304872
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.13

PubMed score by year
PubTator Score  49.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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