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Tchem
MGAT2
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Protein Classes
Protein Summary
Description
Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305386
  • ENSP00000307423
  • ENSG00000168282

Symbol
  • GNT2
  • CDG2A
  • CDGS2
  • GNT-II
  • GLCNACTII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.86
kinase perturbation
0.84
transcription factor binding site profile
0.82
phenotype
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.58   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.58   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 382
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Disease
Diseases associated with N-glycosylation of proteins
Diseases of glycosylation
Protein-Protein Interactions (60)
1 – 10 of 60
PEX19
Tbio
Novelty: 0.00469515
p_int: 0.990627875
p_ni: 0.009372125
Score: 0.212
Data Source: BioPlex,STRINGDB
MAN1A1
Tbio
Family: Enzyme
Novelty: 0.00858736
p_int: 0.979652051
p_ni: 0.020347949
Score: 0.23
Data Source: BioPlex,STRINGDB
TOR1AIP2
Tbio
Novelty: 0.17774016
p_int: 0.768838023
p_ni: 0.231161977
Score: 0.189
Data Source: BioPlex,STRINGDB
MGAT3
Tchem
Family: Enzyme
Novelty: 0.05348617
Score: 0.98
Data Source: STRINGDB
MGAT4B
Tbio
Family: Enzyme
Novelty: 0.14699175
Score: 0.976
Data Source: STRINGDB
MGAT4A
Tbio
Family: Enzyme
Novelty: 0.0650776
Score: 0.976
Data Source: STRINGDB
FUT8
Tbio
Family: Enzyme
Novelty: 0.00956155
Score: 0.967
Data Source: STRINGDB
MAN2A1
Tbio
Family: Enzyme
Novelty: 0.06561713
Score: 0.966
Data Source: STRINGDB
MGAT4D
Tdark
Family: Enzyme
Novelty: 1.6
Score: 0.944
Data Source: STRINGDB
MGAT1
Tchem
Family: Enzyme
Novelty: 0.01240487
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.58

PubMed score by year
PubTator Score  41.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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