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Tbio
NEXN
Nexilin

Protein Summary
Description
Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330010
  • ENSP00000327363
  • ENSG00000162614
  • ENST00000334785
  • ENSP00000333938

Symbol
  • CMH20
  • NELIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
PubMedID
0.76
histone modification site profile
0.75
protein domain
0.73
cellular component
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.17   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.17   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
50.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
50.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nexilin F-actin binding protein
VGNC:9247
456967
Macaque
nexilin F-actin binding protein
710960
Mouse
MGI:1916060
68810
Rat
RGD:708354
246172
Dog
nexilin F-actin binding protein
VGNC:43760
100856678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nexilin F-actin binding protein
Macaque
nexilin F-actin binding protein
Mouse
Rat
Dog
nexilin F-actin binding protein
Protein-Protein Interactions (64)
1 – 10 of 64
GSN
Tbio
Novelty: 0.00060852
p_int: 0.995488925
p_ni: 0.004511075
Score: 0.74
Data Source: BioPlex,STRINGDB
MYO1B
Tbio
Novelty: 0.00761267
p_int: 0.98827433
p_ni: 0.01172567
Score: 0.264
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.986594955
p_ni: 0.013405045
Score: 0.35
Data Source: BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty: 0.04851082
p_int: 0.975973192
p_ni: 0.014748641
p_wrong: 0.009278167
Score: 0.543
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.967570756
p_ni: 0.032429244
Score: 0.281
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.965360406
p_ni: 0.034639593
p_wrong: 2e-9
Data Source: BioPlex
ANK3
Tbio
Novelty: 0.00429246
p_int: 0.948199008
p_ni: 0.051800987
p_wrong: 5e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
ACTR10
Tbio
Novelty: 0.11388846
p_int: 0.917460586
p_ni: 0.082494353
p_wrong: 0.000045061
Score: 0.161
Data Source: BioPlex,STRINGDB
CPVL
Tbio
Family: Enzyme
Novelty: 0.0616903
p_int: 0.890899047
p_ni: 0.109100952
Score: 0.161
Data Source: BioPlex,STRINGDB
LIMA1
Tbio
Novelty: 0.02718476
p_int: 0.888922616
p_ni: 0.111077384
Score: 0.369
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  82.17

PubMed score by year
PubTator Score  72.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer