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Tdark
LAMTOR4
Ragulator complex protein LAMTOR4

Protein Summary
Description
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341942
  • ENSP00000343118
  • ENSG00000188186

Symbol
  • C7orf59
  • C7orf59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
tissue sample
0.59
cell type or tissue
0.58
transcription factor binding site profile
0.56
biological process
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
RRAGD
Tbio
Novelty:  0.04742375
p_int:  0.999999738
p_ni:  2.62e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999994887
p_ni:  0.000005109
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRAGC
Tbio
Novelty:  0.01462756
p_int:  0.999971883
p_ni:  0.000028117
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRAGB
Tbio
Novelty:  0.02279777
p_int:  0.999904647
p_ni:  0.000095353
Score:  0.999
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999773691
p_ni:  0.000225473
p_wrong:  8.37e-7
Score:  0.615
Data Source:  BioPlex,STRINGDB
BORCS5
Tdark
Novelty:  0.59333419
p_int:  0.999722042
p_ni:  0.000277958
Score:  0.297
Data Source:  BioPlex,STRINGDB
SLC38A9
Tbio
Family:  Transporter
Novelty:  0.0879703
p_int:  0.999655856
p_ni:  0.000336731
p_wrong:  0.000007413
Score:  0.999
Data Source:  BioPlex,STRINGDB
BIRC5
Tchem
Novelty:  0.00332112
p_int:  0.999467703
p_ni:  0.000532295
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
BORCS7
Tbio
Novelty:  0.14135922
p_int:  0.999363201
p_ni:  0.000636799
Score:  0.251
Data Source:  BioPlex,STRINGDB
FNIP2
Tbio
Novelty:  0.09918628
p_int:  0.998995493
p_ni:  0.000001291
p_wrong:  0.001003216
Score:  0.311
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
78.3
FEV/FEC ratio
1
1
1
62.5
ticagrelor measurement
1
1
1
36.5
dehydroepiandrosterone sulphate measurement
1
1
1
21.5
family history of Alzheimer’s disease
1
1
0
5.5
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
78.3
FEV/FEC ratio
1
62.5
ticagrelor measurement
1
36.5
dehydroepiandrosterone sulphate measurement
1
21.5
family history of Alzheimer’s disease
0
5.5
17.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
719122
Mouse
MGI:1913346
66096
Rat
RGD:1309735
360776
Dog
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
VGNC:42579
479736
Cow
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
VGNC:30782
511903
Species
Name
OMA
EggNOG
Inparanoid
Macaque
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Mouse
Rat
Dog
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Cow
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Publication Statistics
PubMed Score 4.17
PubMed score by year
PubTator Score 1.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title