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Tbio
HSPA14
Heat shock 70 kDa protein 14

Protein Summary
Description
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378372
  • ENSP00000367623
  • ENSG00000187522

Symbol
  • HSP60
  • HSP70L1
  • HSP70-4
  • HSP70L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.91
transcription factor perturbation
0.8
molecular function
0.76
disease perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.71   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.71   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 14
VGNC:4714
450318
Macaque
heat shock protein family A (Hsp70) member 14
697257
Mouse
MGI:1354164
50497
Rat
RGD:1303296
307133
Dog
heat shock protein family A (Hsp70) member 14
VGNC:52137
477996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 14
Macaque
heat shock protein family A (Hsp70) member 14
Mouse
Rat
Dog
heat shock protein family A (Hsp70) member 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q0VDF9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (193)
1 – 10 of 193
DNAJC2
Tbio
Family: TF
Novelty: 0.01515066
p_int: 0.999999842
p_ni: 2.9e-8
p_wrong: 1.29e-7
Score: 0.993
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.99999262
p_ni: 0.00000738
Data Source: BioPlex
ASIC4
Tbio
Family: IC
Novelty: 0.02912816
p_int: 0.999927489
p_ni: 0.000072511
Data Source: BioPlex
RELL2
Tbio
Novelty: 0.59290726
p_int: 0.999152566
p_ni: 0.000847434
Score: 0.152
Data Source: BioPlex,STRINGDB
NFAM1
Tbio
Novelty: 0.24235123
p_int: 0.998758739
p_ni: 0.001236278
p_wrong: 0.000004983
Score: 0.538
Data Source: BioPlex,STRINGDB
TAB2
Tbio
Family: Enzyme
Novelty: 0.00635786
p_int: 0.998584553
p_ni: 0.001415342
p_wrong: 1.04e-7
Data Source: BioPlex
CYB5A
Tbio
Novelty: 0.00047376
p_int: 0.991417582
p_ni: 0.008579967
p_wrong: 0.000002451
Score: 0.224
Data Source: BioPlex,STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
p_int: 0.979780759
p_ni: 0.020219241
Data Source: BioPlex
SET
Tbio
Novelty: 0.01012327
p_int: 0.974093329
p_ni: 0.025906662
p_wrong: 9e-9
Score: 0.279
Data Source: BioPlex,STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
p_int: 0.960361304
p_ni: 0.039638686
p_wrong: 1.1e-8
Score: 0.237
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  55.71

PubMed score by year
PubTator Score  13.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer