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Tdark
DNAH14
Dynein heavy chain 14, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366848
  • ENSP00000355813
  • ENSG00000185842
  • ENST00000366850
  • ENSP00000355815
  • ENST00000400952
  • ENSP00000383737
  • ENST00000430092
  • ENSP00000414402
  • ENST00000439375
  • ENSP00000392061
  • ENST00000445597
  • ENSP00000409472

Symbol
  • C1orf67
  • HL18
  • HL-18
  • C1orf67
  • Dnahc14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.73
cell line
0.65
cellular component
0.65
histone modification site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.67   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.67   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.999993319
p_ni:  0.000006614
p_wrong:  6.7e-8
Data Source:  BioPlex
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999953187
p_ni:  0.000046808
p_wrong:  5e-9
Data Source:  BioPlex
IGSF8
Tbio
Novelty:  0.03016623
p_int:  0.999724323
p_ni:  0.000275677
Score:  0.204
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999606572
p_ni:  0.000393427
p_wrong:  1e-9
Data Source:  BioPlex
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999333441
p_ni:  0.000666558
Data Source:  BioPlex
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.999258209
p_ni:  0.000741791
Score:  0.534
Data Source:  BioPlex,STRINGDB
RELL2
Tbio
Novelty:  0.59290726
p_int:  0.998849234
p_ni:  0.001142615
p_wrong:  0.000008151
Score:  0.179
Data Source:  BioPlex,STRINGDB
MICB
Tbio
Novelty:  0.00364639
p_int:  0.997190631
p_ni:  0.002674302
p_wrong:  0.000135067
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.997012945
p_ni:  0.002857553
p_wrong:  0.000129502
Data Source:  BioPlex
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.996504648
p_ni:  0.003370586
p_wrong:  0.000124766
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
62.8
feeling nervous measurement
1
1
0
5.9
31.4
body height
1
1
1
17.8
mean corpuscular volume
1
1
1
9.5
mathematical ability
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
62.8
feeling nervous measurement
0
5.9
31.4
body height
1
17.8
mean corpuscular volume
1
9.5
mathematical ability
1
3.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 4.67
PubMed score by year
PubTator Score 5.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title