Tbio INCA1 Protein INCA1

Protein Summary

Description

Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity).

Uniprot Accession IDs

• Q0VD86
• Q6J273
• Q6PKN9

Gene Name

• INCA1

Ensembl ID

• ENST00000355025
• ENSP00000347129
• ENSG00000196388
• ENST00000574617
• ENSP00000458316
• ENST00000575780
• ENSP00000461844
• ENST00000576820
• ENSP00000460673

Symbol

• HSD45

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.62
tissue sample	0.59
histone modification site profile	0.54
biological process	0.51
molecular function	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.5   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.5   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0