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Tbio
APOBR
Apolipoprotein B receptor

Protein Summary
Description
Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431282
  • ENSP00000416094
  • ENSG00000184730
  • ENST00000564831
  • ENSP00000457539

Symbol
  • APOB48R
  • APOB48R
  • APOB100R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
transcription factor
0.66
cellular component
0.46
tissue
0.46
cell line
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.36   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.36   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
APOB
Tchem
Novelty:  0.00008247
Score:  0.962
Data Source:  STRINGDB
APOC4
Tbio
Novelty:  0.06304082
Score:  0.9
Data Source:  Reactome,STRINGDB
APOC1
Tbio
Novelty:  0.00338935
Score:  0.9
Data Source:  Reactome,STRINGDB
LDLR
Tchem
Novelty:  0.06585434
Score:  0.675
Data Source:  STRINGDB
GPIHBP1
Tbio
Novelty:  0.01241227
Score:  0.66
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.622
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.587
Data Source:  STRINGDB
SH2B1
Tbio
Novelty:  0.01659457
Score:  0.584
Data Source:  STRINGDB
APOM
Tbio
Novelty:  0.00505937
Score:  0.582
Data Source:  STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
Score:  0.574
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Plasma lipoprotein assembly, remodeling, and clearance (R-HSA-174824)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Transport of small molecules
Reactome
VLDL clearance
Name
Explore in Pharos
Explore in Source
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Transport of small molecules
VLDL clearance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
3
3
97
mean platelet volume
3
2
3
95.2
platelet crit
2
2
3
91.9
intelligence
3
11
5
6.3
90.9
2
2
0
1.1
86.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
97
mean platelet volume
3
95.2
platelet crit
3
91.9
intelligence
5
6.3
90.9
0
1.1
86.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
apolipoprotein B receptor
705950
Mouse
MGI:2176230
171504
Rat
RGD:1565169
499264
Dog
apolipoprotein B receptor
VGNC:37998
489950
Horse
apolipoprotein B receptor
VGNC:15420
100066345
Species
Name
OMA
EggNOG
Inparanoid
Macaque
apolipoprotein B receptor
Mouse
Rat
Dog
apolipoprotein B receptor
Horse
apolipoprotein B receptor
Publication Statistics
PubMed Score 17.36
PubMed score by year
PubTator Score 11.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title